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To the best of our knowledge, this is the first report documenting the successful treatment of an adult patient with HLH due to disseminated histoplasmosis using etoposide chemotherapy after initial antifungal therapy failed to show improvement.<\/jats:p>","DOI":"10.1136\/bcr-2020-235144","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T02:35:25Z","timestamp":1599100525000},"page":"e235144","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Desperate times, desperate measures: successful use of chemotherapy in treatment of haemophagocytic lymphohistiocytosis (HLH) due to disseminated histoplasmosis"],"prefix":"10.1136","volume":"13","author":[{"given":"Sunny Rajendra Kumar","family":"Singh","sequence":"first","affiliation":[{"name":"Haematology and Oncology, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kannan","family":"Thanikachalam","sequence":"additional","affiliation":[{"name":"Haematology and Oncology, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayalakshmi","family":"Donthireddy","sequence":"additional","affiliation":[{"name":"Haematology and Oncology, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"2025082710153540000_13.9.e235144.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23911"},{"key":"2025082710153540000_13.9.e235144.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70290-6"},{"key":"2025082710153540000_13.9.e235144.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-551622"},{"key":"2025082710153540000_13.9.e235144.4","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"2025082710153540000_13.9.e235144.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0172"},{"key":"2025082710153540000_13.9.e235144.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.04.034"},{"key":"2025082710153540000_13.9.e235144.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.12.012"},{"key":"2025082710153540000_13.9.e235144.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137422"},{"key":"2025082710153540000_13.9.e235144.9","doi-asserted-by":"crossref","first-page":"S194","DOI":"10.1086\/429996","article-title":"Reactivation of latent granulomatous infections by infliximab","volume":"41 Suppl 3","author":"Wallis","year":"2005","journal-title":"Clin Infect Dis"},{"key":"2025082710153540000_13.9.e235144.10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3201\/eid2206.151682","article-title":"Hemophagocytic lymphohistiocytosis and progressive disseminated histoplasmosis","volume":"22","author":"Ferguson-Paul","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"2025082710153540000_13.9.e235144.11","doi-asserted-by":"publisher","DOI":"10.1177\/2325957415570740"},{"key":"2025082710153540000_13.9.e235144.12","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv055"},{"key":"2025082710153540000_13.9.e235144.13","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-221264","article-title":"Safe usage of anakinra and dexamethasone to treat refractory hemophagocytic lymphohistiocytosis secondary to acute disseminated histoplasmosis in a patient with HIV\/AIDS","volume":"30","author":"Ocon","year":"2017","journal-title":"BMJ Case Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-235144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:15:43Z","timestamp":1756314943000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-235144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,2]]},"published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/bcr-2020-235144"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-235144","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}