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A 34-year-old nulligravid woman was referred with a large mass bulging in the fornix posterior. Ultrasound scanning and MRI showed a large solid mass projecting in the pouch of Douglas. Laparoscopic surgical excision was performed. Histopathological examination showed a well-demarcated, unencapsulated tumour, consisting of short fascicles of spindle cells in-between thick-walled medium-sized vessels. On immunohistochemistry, there was strong reactivity with antibodies against CD34 and oestrogen receptor. Angiofibromas are benign mesenchymal tumours mostly occurring in middle-aged women. They can cause abnormal swelling and uterine bleeding and need to be distinguished from other (malignant) neoplasms.<\/jats:p>","DOI":"10.1136\/bcr-2020-235241","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T02:41:18Z","timestamp":1594953678000},"page":"e235241","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Cervicovaginal cellular angiofibroma"],"prefix":"10.1136","volume":"13","author":[{"given":"Sarah","family":"Van Mulders","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Antwerp, Edegem, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Faes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Antwerp, Edegem, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-8061","authenticated-orcid":false,"given":"Glenn","family":"Broeckx","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Antwerp, Edegem, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Jacquemyn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Antwerp, Edegem, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"2025082800525568000_13.7.e235241.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199706000-00002"},{"key":"2025082800525568000_13.7.e235241.2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/1486387","article-title":"Angiofibroma of the vagina presenting with abnormal vaginal bleeding: a case report from Ethiopia and review of the literature","volume":"2019","author":"Arega","year":"2019","journal-title":"Case Rep Obstet Gynecol"},{"key":"2025082800525568000_13.7.e235241.3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/PAS.0b013e3181d74bdb","article-title":"Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases","volume":"34","author":"Chen","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"2025082800525568000_13.7.e235241.4","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00085.x"},{"key":"2025082800525568000_13.7.e235241.5","doi-asserted-by":"crossref","DOI":"10.1186\/s13000-015-0361-6","article-title":"Cellular angiofibroma in women: a review of the literature","volume":"10","author":"Mandato","year":"2015","journal-title":"Diagn Pathol"},{"key":"2025082800525568000_13.7.e235241.6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/cup.12507","article-title":"Genital soft tissue tumors","volume":"42","author":"Schoolmeester","year":"2015","journal-title":"J Cutan Pathol"},{"key":"2025082800525568000_13.7.e235241.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01923.x"},{"key":"2025082800525568000_13.7.e235241.8","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.6.477-b"},{"key":"2025082800525568000_13.7.e235241.9","unstructured":"Kurman RJ , Ellenson LH , Ronett BM . 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