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Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia and attenuated psychotic symptoms despite ongoing treatment with cognitive behavioural therapy and mirtazapine who was treated with adjunctive cannabidiol (CBD) in doses between 200 and 800 mg\/day for 6 months. During treatment with CBD, he experienced subjective benefits to his anxiety, depression and positive symptoms during treatment that were confirmed by clinicians and by standardised research instruments. Findings from this case study add to existing evidence in support of the safety of CBD and suggest that it may be useful for young people with treatment refractory anxiety and for attenuated psychotic symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2020-235307","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T17:30:22Z","timestamp":1602091822000},"page":"e235307","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol"],"prefix":"10.1136","volume":"13","author":[{"given":"Maximus","family":"Berger","sequence":"first","affiliation":[{"name":"Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Orygen, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Orygen, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter Paul","family":"Amminger","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Orygen, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"2025082708444741000_13.10.e235307.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.09.017"},{"key":"2025082708444741000_13.10.e235307.2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200109000-00018"},{"key":"2025082708444741000_13.10.e235307.3","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0889-2"},{"key":"2025082708444741000_13.10.e235307.4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1001\/jamapsychiatry.2013.4186","article-title":"Naturalistic follow-up of youths treated for pediatric anxiety disorders","volume":"71","author":"Ginsburg","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"2025082708444741000_13.10.e235307.5","first-page":"Cd004690","article-title":"Cognitive behavioural therapy for anxiety disorders in children and adolescents","volume":"2","author":"James","year":"2015","journal-title":"Cochrane Databas Syst Rev"},{"key":"2025082708444741000_13.10.e235307.6","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.17r12064","article-title":"Efficacy and tolerability of pharmacotherapy for pediatric anxiety disorders: a network meta-analysis","volume":"80","author":"Dobson","year":"2019","journal-title":"J Clin Psychiatry"},{"key":"2025082708444741000_13.10.e235307.7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13030418"},{"key":"2025082708444741000_13.10.e235307.8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/eip.12274","article-title":"Anxiety in youth at clinical high risk for psychosis","volume":"11","author":"McAusland","year":"2017","journal-title":"Early Interv Psychiatry"},{"key":"2025082708444741000_13.10.e235307.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.10.002"},{"key":"2025082708444741000_13.10.e235307.10","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.6"},{"key":"2025082708444741000_13.10.e235307.11","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0387-1"},{"key":"2025082708444741000_13.10.e235307.12","doi-asserted-by":"crossref","DOI":"10.7812\/TPP\/18-041","article-title":"Cannabidiol in anxiety and sleep: a large case series","volume":"23","author":"Shannon","year":"2019","journal-title":"Perm J"},{"key":"2025082708444741000_13.10.e235307.13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.7812\/TPP\/16-005","article-title":"Effectiveness of cannabidiol oil for pediatric anxiety and insomnia as part of posttraumatic stress disorder: a case report","volume":"20","author":"Shannon","year":"2016","journal-title":"Perm J"},{"key":"2025082708444741000_13.10.e235307.14","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1038\/tp.2012.15","article-title":"Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia","volume":"2","author":"Leweke","year":"2012","journal-title":"Transl Psychiatry"},{"key":"2025082708444741000_13.10.e235307.15","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17030325"},{"key":"2025082708444741000_13.10.e235307.16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/1039856217698237","article-title":"Novel biotherapies are needed in youth mental health","volume":"25","author":"Amminger","year":"2017","journal-title":"Australas Psychiatry"},{"key":"2025082708444741000_13.10.e235307.17","unstructured":"Australian Psychological Society . 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