{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:22:32Z","timestamp":1764588152111,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,9,28]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Gestational breast cancer (GBC) is the most common form of invasive cancer in pregnancy and has unique challenges in both staging and treatment given the dual goal of appropriate cancer management and minimising the risk of fetal toxicity. A 38-year-old woman with no significant medical history and 21 weeks pregnant presented with a palpable right breast mass. She was diagnosed with human epidermal growth factor receptor 2-positive infiltrating ductal carcinoma with advanced disease. The patient underwent treatment; however, unfortunately, she passed away after developing devastating distant disease recurrence.<\/jats:p>\n               <jats:p>We highlight both the challenges and current guidelines for management of GBC. Our goal is to discuss the current limitations of GBC management and the necessity of further investigation for safe novel imaging and treatment modalities for pregnant women. It is crucial to increase awareness across multiple subspecialities, as a multidisciplinary team is necessary for proper treatment of GBC.<\/jats:p>","DOI":"10.1136\/bcr-2020-235308","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T03:15:38Z","timestamp":1604459738000},"page":"e235308","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Gestational breast cancer: current challenges in staging and treatment of breast cancer"],"prefix":"10.1136","volume":"13","author":[{"given":"Aimee","family":"Schad","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Slostad","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Stem Cell Transplant, Rush University Medical Center, Chicago, IL, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Stem Cell Transplant, Rush University Medical Center, Chicago, IL, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"2025082723441608000_13.11.e235308.1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ogc.2013.05.006","article-title":"Breast cancer in pregnancy","volume":"40","author":"Krishna","year":"2013","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2025082723441608000_13.11.e235308.2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4224-6"},{"key":"2025082723441608000_13.11.e235308.3","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0515"},{"key":"2025082723441608000_13.11.e235308.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.06.004"},{"key":"2025082723441608000_13.11.e235308.5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10549-016-3989-3","article-title":"The prognosis of women diagnosed with breast cancer before, during and after pregnancy: a meta-analysis","volume":"160","author":"Hartman","year":"2016","journal-title":"Breast Cancer Res Treat"},{"key":"2025082723441608000_13.11.e235308.6","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0340"},{"key":"2025082723441608000_13.11.e235308.7","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0208"},{"key":"2025082723441608000_13.11.e235308.8","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2015150031"},{"key":"2025082723441608000_13.11.e235308.9","unstructured":"Valentin J . Pregnancy and medical radiation. International Commission on radiological protection, 2000. Available: http:\/\/www.icrp.org\/publication.asp?id=ICRP Publication 84"},{"key":"2025082723441608000_13.11.e235308.10","unstructured":"Yoon I , Slesinger TL . Radiation exposure in pregnancy. Treasure Island, FL: StatPearls Publishing, 2019. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551690\/"},{"key":"2025082723441608000_13.11.e235308.11","unstructured":"Gradishar WJ , Anderson BO , Abraham J , et al . NCCN guidelines version 3.2019 breast cancer. National comprehensive cancer network, 2019. Available: https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx"},{"key":"2025082723441608000_13.11.e235308.12","unstructured":"American College of Obstetricians and Gynecologists . Guidelines for diagnostic imaging during pregnancy and lactation, 2017. Available: https:\/\/www.acog.org\/Clinical-Guidance-and-Publications\/Committee-Opinions\/Committee-on-Obstetric-Practice\/Guidelines-for-Diagnostic-Imaging-During-Pregnancy-and-Lactation?IsMobileSet=false"},{"key":"2025082723441608000_13.11.e235308.13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/jamaoncol.2015.2413","article-title":"Breast cancer diagnosed during pregnancy","volume":"1","author":"Loibl","year":"2015","journal-title":"JAMA Oncol"},{"key":"2025082723441608000_13.11.e235308.14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ogc.2018.01.009","article-title":"Cancer in pregnancy","volume":"45","author":"McCormick","year":"2018","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2025082723441608000_13.11.e235308.15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds170"},{"key":"2025082723441608000_13.11.e235308.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2012.09.014"},{"key":"2025082723441608000_13.11.e235308.17","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000572"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-235308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:44:23Z","timestamp":1756363463000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-235308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":17,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,3]]},"published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1136\/bcr-2020-235308"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-235308","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}