{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:25:44Z","timestamp":1782923144030,"version":"3.54.5"},"reference-count":9,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,8,10]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Adrenocortical carcinomas (ACCs) are rare malignancies with an incidence of one to two per million per year. Aldosterone-producing ACCs (APACs) are extremely rare with an incidence less than 1%. We describe a rare case of APAC, presenting with episodic lower-limb weakness and hypertension. Our patient was found to have serum aldosterone levels of 20.8\u2009ng\/dL (2.5\u201315.2) with persistent hypokalaemia and a 9.7\u00d78.3\u00d77.7\u2009cm right adrenal mass, which was suspicious of malignancy on evaluation. He underwent a complete surgical resection which confirmed the diagnosis of ACC and normalised his aldosterone and potassium levels. He was then subjected to postoperative chemotherapy. Postoperative adjuvant chemotherapy with mitotane has a role in preventing recurrence.<\/jats:p>","DOI":"10.1136\/bcr-2020-235317","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T03:38:31Z","timestamp":1599709111000},"page":"e235317","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Potassium losing, aldosterone producing adrenocortical carcinoma: a rare presentation"],"prefix":"10.1136","volume":"13","author":[{"given":"Zahir S","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Madras Medical College and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-5674","authenticated-orcid":false,"given":"Smitha S","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Madras Medical College and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajith Z","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Madras Medical College and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikhil","family":"Puzhakkal","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Madras Medical College and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"2025082713124104000_13.9.e235317.1","first-page":"252","article-title":"Malignant aldosterone-producing adrenal tumour: reoccurrence with glucocorticoid excess without hyperaldosteronism","volume":"66","author":"Abma","year":"2008","journal-title":"Neth J Med"},{"key":"2025082713124104000_13.9.e235317.2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.15605\/jafes.033.01.10","article-title":"Aldosterone-Producing adrenocortical carcinoma","volume":"33","author":"Lazaro","year":"2018","journal-title":"JAFES"},{"key":"2025082713124104000_13.9.e235317.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-016-0083-0","article-title":"Aldosterone-Producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy: a case report","volume":"16","author":"Ohashi","year":"2016","journal-title":"BMC Endocr Disord"},{"key":"2025082713124104000_13.9.e235317.4","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00867"},{"key":"2025082713124104000_13.9.e235317.5","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyr144"},{"key":"2025082713124104000_13.9.e235317.6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s13193-016-0563-8","article-title":"Bilateral aldosterone-producing adrenocortical carcinoma: a rare entity","volume":"8","author":"Daga","year":"2017","journal-title":"Indian J Surg Oncol"},{"key":"2025082713124104000_13.9.e235317.7","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-217918"},{"key":"2025082713124104000_13.9.e235317.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345531"},{"key":"2025082713124104000_13.9.e235317.9","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-18-0608","article-title":"European Society of endocrinology clinical practice guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European network for the study of adrenal tumors","volume":"179","author":"Fassnacht","year":"2018","journal-title":"Eur J Endocrinol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-235317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:12:48Z","timestamp":1756325568000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-235317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,9]]},"published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/bcr-2020-235317"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-235317","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}