{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:39:14Z","timestamp":1780519154670,"version":"3.54.1"},"reference-count":16,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,5,21]]},"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>A rare case of malignant Brenner tumour of ovary manifesting with intestinal perforation due to colonic infiltration is elaborated in the present report. Brenner\u2019s tumour accounts for 1%\u20132% of all ovarian neoplasms and malignant Brenner tumour is even rarer and only about 5% of Brenner tumours are malignant. A 62-year-old woman came to surgical emergency with 1-month history of abdominal pain, vomiting and constipation with a palpable mass in right iliac fossa. Abdominal radiograph was suggestive of colonic obstruction. Contrast-enhanced CT of the abdomen revealed cystic right ovarian mass of 10.2\u00d78.8\u2009cm<jats:sup>2<\/jats:sup> with pneumoperitoneum. Exploratory laparotomy was done, which revealed mass arising from right ovary involving terminal ileum, cecum and ascending colon. Possibility of ovarian malignancy was kept. Patient underwent debulking surgery along with ileostomy and descending colon mucous fistula was created. Histology was compatible with malignant Brenner tumour of the ovary.<\/jats:p>","DOI":"10.1136\/bcr-2020-235394","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T05:55:22Z","timestamp":1591941322000},"page":"e235394","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Malignant Brenner tumour of the ovary manifesting as distal intestinal obstruction and perforation"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9183-2317","authenticated-orcid":false,"given":"Brijesh Kumar","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Saha","sequence":"additional","affiliation":[{"name":"Surgery, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Pathology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashwant Singh","family":"Rathore","sequence":"additional","affiliation":[{"name":"Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"2025082722061906000_13.6.e235394.1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/1097-0142(195603\/04)9:2<217::AID-CNCR2820090202>3.0.CO;2-X","article-title":"Obstetrical-gynecological eponyms: Fritz Brenner and Brenner tumors of the ovary","volume":"9","author":"SPEERT","year":"1956","journal-title":"Cancer"},{"key":"2025082722061906000_13.6.e235394.2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00004347-198703000-00004","article-title":"Malignant Brenner tumor and transitional cell carcinoma of the ovary: a comparison","volume":"6","author":"Austin","year":"1987","journal-title":"Int J Gynecol Pathol"},{"key":"2025082722061906000_13.6.e235394.3","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/PAS.0b013e318188b84c","article-title":"Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas","volume":"33","author":"Cuatrecasas","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"2025082722061906000_13.6.e235394.4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10147-011-0290-7","article-title":"Malignant Brenner tumor of the ovary: analysis of 13 cases","volume":"17","author":"Gezgin\u00e7","year":"2012","journal-title":"Int J Clin Oncol"},{"key":"2025082722061906000_13.6.e235394.5","first-page":"5642","article-title":"Malignant Brenner tumor of the ovary: clinical, pathological and demographic analyses of 10 cases","volume":"9","author":"Yue","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"2025082722061906000_13.6.e235394.6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tjog.2014.03.008","article-title":"Intensive systemic chemotherapy is effective against recurrent malignant Brenner tumor of the ovary: an analysis of 10 cases within a single center","volume":"54","author":"Han","year":"2015","journal-title":"Taiwan J Obstet Gynecol"},{"key":"2025082722061906000_13.6.e235394.7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1159\/000325184","article-title":"Ascitic fluid cytology in malignant Brenner tumor: a case report","volume":"54","author":"Driss","year":"2010","journal-title":"Acta Cytol"},{"key":"2025082722061906000_13.6.e235394.8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jocn.2009.01.038","article-title":"Dural metastases as a presentation of a Brenner tumor","volume":"17","author":"Baizabal-Carvallo","year":"2010","journal-title":"J Clin Neurosci"},{"key":"2025082722061906000_13.6.e235394.9","doi-asserted-by":"crossref","first-page":"584","DOI":"10.4103\/2278-0513.157821","article-title":"Malignant Brenner tumor of ovary: a rare entity","volume":"4","author":"Sangwaiya","year":"2015","journal-title":"Clin Cancer Investig J"},{"key":"2025082722061906000_13.6.e235394.10","unstructured":"Ripamonti C , Mercadante S . 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