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We describe the first-ever participant within the population-based Rotterdam Study diagnosed with sCJD. We retrieved clinical data from both the population-based Rotterdam Study and the National Prion Disease Registry. In 2011, a female participant of the Rotterdam Study was diagnosed with probable sCJD and registered into the Registry. Four months earlier, she was classified as having mild cognitive impairment based on assessment in the Rotterdam Study. Clinical deterioration was rapid, with the patient dying 7\u2009months after the research centre visit. Postmortem brain autopsy confirmed the diagnosis of sCJD. In conclusion, we describe the first case diagnosed with sCJD who during diagnostic workup for sCJD was classified as having mild cognitive impairment in a population-based cohort study.<\/jats:p>","DOI":"10.1136\/bcr-2020-235509","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T11:15:46Z","timestamp":1617016546000},"page":"e235509","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["First participant diagnosed with Creutzfeldt-Jakob disease in the population-based Rotterdam Study was classified with mild cognitive impairment"],"prefix":"10.1136","volume":"14","author":[{"given":"Hata","family":"Karamuji\u0107-\u010comi\u0107","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"},{"name":"National Prion Disease Registry, Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke J M","family":"Rozemuller","sequence":"additional","affiliation":[{"name":"Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Pathology, UMC Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Arfan","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"},{"name":"National Prion Disease Registry, Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M","family":"van Duijn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"},{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"2025082800524234000_14.3.e235509.1","unstructured":"Creutzfeldt-Jakob Disease International Surveillance Network . 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