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Since the first-line agents were contraindicated, plasmapheresis was used to control the thyroid storm and as a bridging therapy to the definitive therapy of early thyroidectomy. This is the first paediatric case report that outlines the use of plasmapheresis in the management of complicated thyrotoxicosis in a setting of septic shock.<\/jats:p>","DOI":"10.1136\/bcr-2020-235536","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T06:04:46Z","timestamp":1594101886000},"page":"e235536","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Sepsis and thyroid storm in a patient with methimazole-induced agranulocytosis"],"prefix":"10.1136","volume":"13","author":[{"given":"Vaishnavi Divya","family":"Nagarajan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawtanya","family":"Pleasant","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Shenoi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"2025082707452268000_13.7.e235536.1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.36-6-239"},{"key":"2025082707452268000_13.7.e235536.2","unstructured":"LaFranchi S , Hoppin AG . 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