{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:31:22Z","timestamp":1782361882152,"version":"3.54.5"},"reference-count":14,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,8,6]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Acute necrotising encephalopathy (ANE) is a rare disease that corresponds to a rapidly progressive encephalopathy induced by a viral infection. It is frequently associated with a mutation on the RAN-binding protein 2 (<jats:italic>RANBP2<\/jats:italic>) gene\u2013ANE1. We present a case of a 5-year-old boy with a clinical picture of influenza aggravated to an acute encephalopathy picture after the 3rd day. Complementary examinations came back positive for the influenza A virus, and MRI showed aspects compatible with ANE. He was treated accordingly with subsequent improvement of the clinical picture. During ambulatory follow-up, a mutation was detected on the <jats:italic>RANBP2<\/jats:italic> gene and, at the ophthalmological level, bilateral peripheral constriction on the campimetry and a significant reduction of bilateral peripapillary retinal nerve fibre layer was reported. Our case contributes to the enrichment of the neuro-ophthalmological literature and expands the spectrum of sequelae of this rare entity in the Caucasian population.<\/jats:p>","DOI":"10.1136\/bcr-2020-235636","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T17:16:08Z","timestamp":1600103768000},"page":"e235636","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Neuro-ophthalmological consequences of acute influenza A encephalitis in a genetically predisposed child"],"prefix":"10.1136","volume":"13","author":[{"given":"Catarina","family":"Xavier","sequence":"first","affiliation":[{"name":"Ophthalmology, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Boncquet Vieira","sequence":"additional","affiliation":[{"name":"Ophthalmology, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Ophthalmology, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Lisboa, Portugal"},{"name":"Ophthalmology, Hospital CUF de Cascais, Cascais, Portugal"},{"name":"Ophthalmology, Hospital CUF Descobertas, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Tavares Ferreira","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital CUF de Cascais, Cascais, Portugal"},{"name":"Ophthalmology, Hospital CUF Descobertas, Lisboa, Portugal"},{"name":"Ophthalmology, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisboa, 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