{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:40:03Z","timestamp":1756312803440,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,9,9]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>A 21-year-old woman was admitted to the department of haematology with fever, generalised body ache and swelling of the feet. She also presented with band-like tightness over the abdomen and was unable to walk for the last 2 days. There was no history of trauma. She was diagnosed as a case of B-cell acute lymphoblastic leukaemia based on flow cytometry and bone marrow studies. MRI of the thoracolumbar spine revealed signal intensity alteration in the spinal cord from D1\u22122 to D5\u22126. Her serum vitamin B<jats:sub>12<\/jats:sub> and folate levels were normal. Autoimmune workup including antinuclear antibody and viral serology, and reverse transcriptase PCR for herpes simplex virus, Epstein-Barr virus and cytomegalovirus were negative. Her cerebrospinal fluid was negative for malignant cells. She was started on Berlin-Frankfurt-Munster 95 protocol and her condition improved along with partial improvement in the power of her limbs at the time of discharge. The neurological diagnosis of non-compressive myelopathy due to myelitis was considered.<\/jats:p>","DOI":"10.1136\/bcr-2020-235754","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T17:11:04Z","timestamp":1604077864000},"page":"e235754","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Non-compressive myelopathy: an unusual presentation of a patient with acute B lymphoblastic leukaemia"],"prefix":"10.1136","volume":"13","author":[{"given":"Avaneesh","family":"Shukla","sequence":"first","affiliation":[{"name":"Clinical Hematology, King George's Medical University, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailendra Prasad","family":"Verma","sequence":"additional","affiliation":[{"name":"Clinical Hematology, King George's Medical University, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durga Prasad","family":"Verma","sequence":"additional","affiliation":[{"name":"Clinical Hematology, King George's Medical University, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Yadav","sequence":"additional","affiliation":[{"name":"Pathology, King George's Medical University, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"2025082709151057000_13.10.e235754.1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.53"},{"key":"2025082709151057000_13.10.e235754.2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12288-012-0221-4","article-title":"A rare case of adult acute lymphoblastic leukemia presenting with paraparesis and multiple osteolytic lesions","volume":"30","author":"Verma","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"key":"2025082709151057000_13.10.e235754.3","doi-asserted-by":"crossref","first-page":"87s","DOI":"10.1200\/jgo.18.42100","article-title":"Unusual presentations of acute lymphoblastic leukemia in children: a study of 9 patients","volume":"4","author":"Maheshwari","year":"2018","journal-title":"J Glob Oncol"},{"key":"2025082709151057000_13.10.e235754.4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0887-8994(01)00258-2","article-title":"Transverse myelopathy: an initial presentation of acute leukemia","volume":"24","author":"Yavuz","year":"2001","journal-title":"Pediatr Neurol"},{"key":"2025082709151057000_13.10.e235754.5","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.20"},{"key":"2025082709151057000_13.10.e235754.6","first-page":"3231","article-title":"Diagnostic approach to myelopathies","volume":"22","author":"Granados","year":"2011","journal-title":"Revista Colombiana de Radiolog\u00eda"},{"key":"2025082709151057000_13.10.e235754.7","article-title":"Non-compressive myelopathy: clinical and radiological study","volume":"47","author":"Prabhakar","year":"1999","journal-title":"Neurol India"},{"key":"2025082709151057000_13.10.e235754.8","first-page":"17","article-title":"[Acute myeloid leukemia with sudden onset bilateral lower extremity paralysis caused by disseminated mucormycosis following unrelated bone marrow transplantation]","volume":"60","author":"Itakusu","year":"2019","journal-title":"Rinsho Ketsueki"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-235754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:15:16Z","timestamp":1756311316000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-235754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":8,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,30]]},"published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1136\/bcr-2020-235754"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-235754","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}