{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:52:08Z","timestamp":1785423128609,"version":"3.56.0"},"reference-count":26,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,9,14]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Placental site trophoblastic tumour (PSTT) is a very rare form of gestational trophoblastic disease that grows slowly, secretes low levels of beta-subunit of human chorionic gonadotropin (\u03b2-hCG), presents late-onset metastatic potential and is resistant to several chemotherapy regimens. Here, we report a case of PSTT in a 36-year-old woman who presented with amenorrhea and persistently elevated serum level of \u03b2-hCG after a miscarriage. Transvaginal ultrasound revealed a hypovascular ill-defined solid lesion of the uterine fundus and MRI showed a tumour infiltrating the external myometrium with discrete early enhancement and signal restriction on diffusion-weighted imaging. PSTT was suspected, and after endometrial biopsy by hysteroscopy and posterior hysterectomy, microscopic examination allowed the final diagnosis. The level of \u03b2-hCG dropped significantly in about a month after surgical treatment. Due to the rarity of PSTT, reporting new cases is crucial to improve the diagnosis and managing of these patients.<\/jats:p>","DOI":"10.1136\/bcr-2020-235756","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T14:25:14Z","timestamp":1602339914000},"page":"e235756","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Placental site trophoblastic tumour: the rarest subtype of gestational trophoblastic disease"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-1299","authenticated-orcid":false,"given":"Mariana M","family":"Chaves","sequence":"first","affiliation":[{"name":"Radiology, Hospital do Divino Espirito Santo de Ponta Delgada EPE, Ponta Delgada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Maia","sequence":"additional","affiliation":[{"name":"Pathology, Instituto Portugu\u00eas de Oncologia de 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