{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:25:12Z","timestamp":1765268712416,"version":"3.44.0"},"reference-count":35,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,10,30]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Neurocutaneous melanosis (NCM) is a rare disorder characterised by giant or multiple melanocytic nevi and meningeal melanosis or melanoma. Onset of neurological symptoms is typically in children younger than 2 years and can be rapidly fatal. We present the case of a 13-year-old adopted girl presenting with numerous congenital melanocytic nevi and a seizure. She had no significant previous neurological history. Electroencephalogram showed epileptiform discharges over the right frontal region. MRI of the brain showed T1 hyperintensity in the bilateral amygdala and anterior temporal lobes with corresponding hyperintensity on T2 and fluid attenuated inversion recovery. There was no hydrocephalus. Along with the history of nevi, these imaging findings were concerning for NCM. The patient is being managed with levetiracetam and trametinib and shows no further neurological decline at 1-year follow-up, providing prognostic hope in this case of NCM.<\/jats:p>","DOI":"10.1136\/bcr-2020-235772","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T15:45:15Z","timestamp":1606751115000},"page":"e235772","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager"],"prefix":"10.1136","volume":"13","author":[{"given":"Aimen","family":"Vanood","sequence":"first","affiliation":[{"name":"Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Banner Desert Medical Center, Mesa, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Leleszi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Beaumont Children's Hospital, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anant","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA"},{"name":"Department of Diagnostic Radiology and Molecular Imaging, Beaumont Hospital, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"2025082702380310000_13.11.e235772.1","first-page":"113","article-title":"Ein ausgezeichneter fall von Pigment-Mal MIT ausgebreiteter Pigmentierung Der inneren Hirn-und R\u00fcckenmarksh\u00e4ute","volume":"1","author":"Rokitansky","year":"1861","journal-title":"Allg Wien Med"},{"key":"2025082702380310000_13.11.e235772.2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1590\/0100-3984.2015.0128","article-title":"Neurocutaneous melanosis","volume":"49","author":"Moreira","year":"2016","journal-title":"Radiol Bras"},{"key":"2025082702380310000_13.11.e235772.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0835-9"},{"key":"2025082702380310000_13.11.e235772.4","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70115-I"},{"key":"2025082702380310000_13.11.e235772.5","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-227621","article-title":"Neurocutaneous melanosis: a rare manifestation of congenital melanocytic nevus","volume":"12","author":"Lee","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025082702380310000_13.11.e235772.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4205-x"},{"key":"2025082702380310000_13.11.e235772.7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00401-012-0945-0","article-title":"Neuropathology of neurocutaneous melanosis: histological foci of melanotic neurones and glia may be undetectable on MRI","volume":"123","author":"Kinsler","year":"2012","journal-title":"Acta Neuropathol"},{"key":"2025082702380310000_13.11.e235772.8","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808319069"},{"key":"2025082702380310000_13.11.e235772.9","first-page":"96","article-title":"Neurocutaneous melanosis presenting with hydrocephalus. 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