{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:40:02Z","timestamp":1756366802204,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,9,3]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>A 26-year-old woman was found to have congenital dysfibrinogenaemia after presenting to our hospital with premature rupture of the membranes and vaginal bleeding. Given the absence of clear guidelines for the management of pregnancy complicated by dysfibrinogenaemia, we followed expert consensus that exists among published works, with some modifications. This case was managed by a multidisciplinary team of obstetrics-gynaecology, haematology and paediatric haematology. Here we review how the patient presented, the investigations that led to the diagnosis and the treatment options.<\/jats:p>","DOI":"10.1136\/bcr-2020-235961","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T17:51:06Z","timestamp":1600451466000},"page":"e235961","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Congenital dysfibrinogenaemia presented with preterm premature rupture of the membranes and vaginal bleeding"],"prefix":"10.1136","volume":"13","author":[{"given":"Zaker I","family":"Schwabkey","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Albany Medical College, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farrell C","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Albany Medical College, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Albany Medical College, Albany, New York, USA"},{"name":"New York Oncology Hematology PC, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihir","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Albany Medical College, Albany, New York, USA"},{"name":"New York Oncology Hematology PC, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082800222918000_13.9.e235961.1","DOI":"10.1111\/jth.12916"},{"key":"2025082800222918000_13.9.e235961.2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/MBC.0b013e328358e96d","article-title":"The dilemma of inherited dysfibrinogenemia during pregnancy","volume":"23","author":"Munoz","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"doi-asserted-by":"publisher","key":"2025082800222918000_13.9.e235961.3","DOI":"10.1111\/j.1365-2516.2008.01831.x"},{"key":"2025082800222918000_13.9.e235961.4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11239-019-01991-x","article-title":"Congenital hypofibrinogenemia associated with a novel heterozygous nonsense mutation in the globular C-terminal domain of the \u03b3-chain (p.Glu275Stop)","volume":"50","author":"Simurda","year":"2020","journal-title":"J Thromb Thrombolysis"},{"key":"2025082800222918000_13.9.e235961.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MBC.0000000000000392","article-title":"Yes or no for secondary prophylaxis in afibrinogenemia?","volume":"26","author":"Simurda","year":"2015","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2025082800222918000_13.9.e235961.6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000452864","article-title":"Thrombosis in inherited fibrinogen disorders","volume":"44","author":"Korte","year":"2017","journal-title":"Transfus Med Hemother"},{"key":"2025082800222918000_13.9.e235961.7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.mbc.0000224841.48463.be","article-title":"Inherited abnormalities of fibrinogen: 10-year clinical experience of an Italian group","volume":"17","author":"Santacroce","year":"2006","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2025082800222918000_13.9.e235961.8","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1160\/TH14-10-0849","article-title":"Novel FGG variant (\u03b3339C\u2192S) confirms importance of the \u03b3326-339 disulphide bond for plasma expression of newly synthesised fibrinogen","volume":"113","author":"Brennan","year":"2015","journal-title":"Thromb Haemost"},{"key":"2025082800222918000_13.9.e235961.9","first-page":"519","article-title":"Congenital hypofibrinogenemia and recurrent placental abruption","volume":"61","author":"Ness","year":"1983","journal-title":"Obstet Gynecol"},{"key":"2025082800222918000_13.9.e235961.10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.transci.2004.08.003","article-title":"Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency","volume":"32","author":"Kreuz","year":"2005","journal-title":"Transfus Apher Sci"},{"key":"2025082800222918000_13.9.e235961.11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1055\/s-0038-1653741","article-title":"Familial dysfibrinogenemia and thrombophilia. 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