{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:51:29Z","timestamp":1782964289662,"version":"3.54.5"},"reference-count":15,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,12]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>We present a 9-year-old male child having history of fractures on trivial trauma with a family history of the same. He was treated for osteogenesis imperfecta (OI; zolendronate, calcium and vitamin D) and showed clinical improvement. On evaluating his bone health using dual energy X-ray absorptiometry and peripheral quantitative CT, we found that the child had bone density within the reference range but a smaller bone mass for his height, low muscle mass and thin bones with a lower strength strain index in comparison with healthy children. Our case suggests that treatment with bisphosphonates results in increase in bone density; however, bones remain thin and the lean body mass in these children may also be low. Controlled physical activity to improve muscle health and newer approaches to improve bone geometry would result in better bone health in children with OI.<\/jats:p>","DOI":"10.1136\/bcr-2020-236169","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T23:30:29Z","timestamp":1607902229000},"page":"e236169","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive evaluation of bone health using DXA and pQCT in an Indian boy with osteogenesis imperfecta"],"prefix":"10.1136","volume":"13","author":[{"given":"Madhura Bharat","family":"Karguppikar","sequence":"first","affiliation":[{"name":"Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Ekbote","sequence":"additional","affiliation":[{"name":"Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-3235","authenticated-orcid":false,"given":"Anuradha","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India"},{"name":"Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaman","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India"},{"name":"Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,13]]},"reference":[{"key":"2025082804144020000_13.12.e236169.1","doi-asserted-by":"crossref","unstructured":"Marini JC , Letocha AD , Chernoff EJ . Osteogenesis imperfecta. In: Management of genetic syndromes, 2005.","DOI":"10.1002\/0471695998.mgs034"},{"key":"2025082804144020000_13.12.e236169.2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11914-007-0023-z","article-title":"Osteogenesis imperfecta:epidemiology and pathophysiology","volume":"5","author":"Martin","year":"2007","journal-title":"Curr Osteoporos Rep"},{"key":"2025082804144020000_13.12.e236169.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1681-7"},{"key":"2025082804144020000_13.12.e236169.4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jbmr.2935","article-title":"Amalgamated reference data for Size-Adjusted bone densitometry measurements in 3598 children and young Adults-the alphabet study","volume":"32","author":"Crabtree","year":"2017","journal-title":"J Bone Miner Res"},{"key":"2025082804144020000_13.12.e236169.5","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/540178","article-title":"Genotype-phenotype correlations in autosomal dominant osteogenesis imperfecta","volume":"2011","author":"Ben Amor","year":"2011","journal-title":"J Osteoporos"},{"key":"2025082804144020000_13.12.e236169.6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bone.2014.09.003","article-title":"Increased intra-cortical porosity reduces bone stiffness and strength in pediatric patients with osteogenesis imperfecta","volume":"69","author":"Vardakastani","year":"2014","journal-title":"Bone"},{"key":"2025082804144020000_13.12.e236169.7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jbiomech.2017.09.003","article-title":"Macroscopic anisotropic bone material properties in children with severe osteogenesis imperfecta","volume":"64","author":"Albert","year":"2017","journal-title":"J Biomech"},{"key":"2025082804144020000_13.12.e236169.8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2023I"},{"key":"2025082804144020000_13.12.e236169.9","doi-asserted-by":"crossref","unstructured":"Crabtree NJ , Leonard MB , Zemel BS . Dual-Energy X-Ray Absorptiometry. In: Sawyer AJ , Bachrach LK , Fung EB , eds. Bone densitometry in growing patients. current clinical practice. Humana Press, 2007.","DOI":"10.1007\/978-1-59745-211-3_3"},{"key":"2025082804144020000_13.12.e236169.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1845-0"},{"key":"2025082804144020000_13.12.e236169.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.002"},{"key":"2025082804144020000_13.12.e236169.12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bone.2015.05.019","article-title":"The functional muscle-bone unit in patients with osteogenesis imperfecta type I","volume":"79","author":"Veilleux","year":"2015","journal-title":"Bone"},{"key":"2025082804144020000_13.12.e236169.13","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jbmr.1592","article-title":"Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT","volume":"27","author":"Folkestad","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2025082804144020000_13.12.e236169.14","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00198-015-3156-4","article-title":"Bone structure assessed by HR-pQCT, tbs and DXL in adult patients with different types of osteogenesis imperfecta","volume":"26","author":"Kocijan","year":"2015","journal-title":"Osteoporos Int"},{"key":"2025082804144020000_13.12.e236169.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.08.003"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-236169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:14:50Z","timestamp":1756379690000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-236169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,13]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1136\/bcr-2020-236169"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-236169","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}