{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:08:53Z","timestamp":1780942133696,"version":"3.54.1"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,28]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Leptomeningeal carcinomatosis is a devastating sequelae of metastatic cancer. It has protean manifestations on imaging. An elderly woman presented to our tertiary centre with symptoms suggestive of a cerebrovascular accident. Investigations revealed no evidence of this. There was clinical, contextual and radiological evidence of an underlying neoplasm.<\/jats:p>\n               <jats:p>Magnetic resonance imaging (MRI) demonstrated evidence of a rare morphology (anterolateral pontine leptomeningeal enhancement) in the presence of a probable concomitant lung adenocarcinoma. Other reports have previously described this same neuroradiology, seemingly always in association with lung adenocarcinoma.<\/jats:p>\n               <jats:p>The purpose of this report is to highlight an unusual case and discuss its peculiarity and pathophysiology. Our patient is the latest documented of a small cohort with this constellation of clinical and neuroradiological features.<\/jats:p>\n               <jats:p>This study demonstrates the importance of differential diagnosis in stroke medicine, specifically the need to consider neoplastic phenomena in patients admitted following putative cerebrovascular events.<\/jats:p>","DOI":"10.1136\/bcr-2020-236265","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T12:00:36Z","timestamp":1610971236000},"page":"e236265","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["T2-hyperintense, non-gadolinium-enhancing, diffusion-restricted symmetrical curvilinear lesion of the anterior pons: a rare radiological pattern of leptomeningeal metastatic disease secondary to likely lung adenocarcinoma"],"prefix":"10.1136","volume":"14","author":[{"given":"Christopher Alan","family":"Brooks","sequence":"first","affiliation":[{"name":"Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia"},{"name":"Neurosurgery, Liverpool Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bonura","sequence":"additional","affiliation":[{"name":"Radiology, Liverpool Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-0606","authenticated-orcid":false,"given":"Roy G","family":"Beran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia"},{"name":"Medical, Griffith University Griffith Health, Gold Coast, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2025082708413785000_14.1.e236265.1","doi-asserted-by":"publisher","DOI":"10.1177\/1941874415591702"},{"key":"2025082708413785000_14.1.e236265.2","doi-asserted-by":"crossref","first-page":"73312","DOI":"10.18632\/oncotarget.20272","article-title":"Leptomeningeal disease: current diagnostic and therapeutic strategies","volume":"8","author":"Nayar","year":"2017","journal-title":"Oncotarget"},{"key":"2025082708413785000_14.1.e236265.3","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2019-000507"},{"key":"2025082708413785000_14.1.e236265.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(99)91181-9"},{"key":"2025082708413785000_14.1.e236265.5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.3.385"},{"key":"2025082708413785000_14.1.e236265.6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neurad.2014.05.003","article-title":"Exceptional symmetric anterior brainstem involvement in leptomeningeal carcinomatosis","volume":"41","author":"Crombe","year":"2014","journal-title":"J Neuroradiol"},{"key":"2025082708413785000_14.1.e236265.7","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001053","article-title":"Symmetrical curvilinear cytotoxic edema along the surface of the brain stem: a probable new magnetic resonance imaging finding of leptomeningeal carcinomatosis","volume":"94","author":"Khil","year":"2015","journal-title":"Medicine"},{"key":"2025082708413785000_14.1.e236265.8","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2017.00579","article-title":"Novel anterior brainstem magnetic resonance imaging findings in non-small cell lung cancer with leptomeningeal carcinomatosis","volume":"8","author":"Cheng","year":"2017","journal-title":"Front Neurol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-236265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:41:44Z","timestamp":1756309304000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-236265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-236265"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-236265","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}