{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:17:27Z","timestamp":1788488247894,"version":"build-2803163510"},"reference-count":16,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,24]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>A young third gravida was referred with prenatal diagnosis of factor XIII deficiency at 20 weeks of pregnancy for Medical Termination of Pregnancy (MTP). Her first baby, who was born by emergency Lower Segment Caesarean Section (LSCS) for fetal distress, had intracranial haemorrhage in the early neonatal period and was investigated elsewhere and diagnosed to have factor XIII deficiency. The child currently has global developmental delay and cerebral palsy. The mother had a second-degree consanguineous marriage and the couple were diagnosed to be carriers of factor XIII deficiency. She had lot of barriers to get prenatal diagnosis during the second pregnancy and it ended up in Intra Uterine Fetal Death (IUFD) at 27 weeks. During the current pregnancy, prenatal diagnosis (PND) was done only after the second trimester amniocentesis and the genetic mutation was F13 A1, Ex12, C.1687 G&gt;A. Second trimester MTP in a previous scarred uterus was difficult as it is essential to avoid scar rupture. PND during the first trimester is ideal.<\/jats:p>","DOI":"10.1136\/bcr-2020-236365","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:18:21Z","timestamp":1608661101000},"page":"e236365","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal diagnosis of factor 13 deficiency and its recurrence"],"prefix":"10.1136","volume":"13","author":[{"given":"Papa","family":"Dasari","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology, JIPMER, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sairem","family":"Mangolngnbi Chanu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, JIPMER, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmi Prasanna","family":"Gadipudi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, JIPMER, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2025082803023018000_13.12.e236365.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.108.2802.280"},{"key":"2025082803023018000_13.12.e236365.2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1395350"},{"key":"2025082803023018000_13.12.e236365.3","doi-asserted-by":"publisher","DOI":"10.1136\/fn.80.3.F238"},{"key":"2025082803023018000_13.12.e236365.4","first-page":"324","article-title":"Diagnosis and management of severe congenital factor XIII deficiency in the Emergency Department: lessons from a \"model\" family","volume":"13","author":"Bertamino","year":"2015","journal-title":"Blood Transfus"},{"key":"2025082803023018000_13.12.e236365.5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.5.560"},{"key":"2025082803023018000_13.12.e236365.6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/10245332.2017.1422315","article-title":"Pathogenicity analysis of variations and prenatal diagnosis in a hereditary coagulation factor XIII deficiency family","volume":"23","author":"Sun","year":"2018","journal-title":"Hematology"},{"key":"2025082803023018000_13.12.e236365.7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/10245332.2015.1101975","article-title":"Diagnosis of factor XIII deficiency","volume":"21","author":"Dorgalaleh","year":"2016","journal-title":"Hematology"},{"key":"2025082803023018000_13.12.e236365.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.02.009"},{"key":"2025082803023018000_13.12.e236365.9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01.ogx.0000259176.03156.2b","article-title":"Congenital blood coagulation factor XIII deficiency and successful deliveries: a review of the literature","volume":"62","author":"Asahina","year":"2007","journal-title":"Obstet Gynecol Surv"},{"key":"2025082803023018000_13.12.e236365.10","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13058"},{"key":"2025082803023018000_13.12.e236365.11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/JBM.S32693","article-title":"New developments in the management of congenital factor XIII deficiency","volume":"4","author":"Fadoo","year":"2013","journal-title":"J Blood Med"},{"key":"2025082803023018000_13.12.e236365.12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/1110-1067.164742","article-title":"Factor XIII deficiency: the first case reported form Nepal","volume":"40","author":"Poudayal","year":"2015","journal-title":"Egypt J Haematol"},{"key":"2025082803023018000_13.12.e236365.13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.17659\/01.2017.0085","article-title":"Factor XIII deficiency presenting as intra-cerebral haemorrhage","volume":"7","author":"Sudev","year":"2017","journal-title":"JCR"},{"key":"2025082803023018000_13.12.e236365.14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5005\/jp-journals-10005-1760","article-title":"Dental management of factor XIII deficiency patients: a case series","volume":"13","author":"Pai","year":"2020","journal-title":"Int J Clin Pediatr Dent"},{"key":"2025082803023018000_13.12.e236365.15","unstructured":"Mangla A , Hamad H , Kumar A . Factor XIII deficiency. 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