{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:06:44Z","timestamp":1791576404141,"version":"4.3.4"},"reference-count":14,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,8,24]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                  <jats:italic>Mycoplasmatacea<\/jats:italic> family comprises two genera: <jats:italic>Mycoplasma<\/jats:italic> and <jats:italic>Ureaplasma<\/jats:italic>. <jats:italic>Ureaplasma parvum<\/jats:italic> (previously known as <jats:italic>U. urealyticum biovar 1<\/jats:italic>) commonly colonises the urogenital tract in humans. Although <jats:italic>Ureaplasma<\/jats:italic> species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to <jats:italic>U. parvum<\/jats:italic> identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of <jats:italic>Ureaplasma<\/jats:italic> septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.<\/jats:p>","DOI":"10.1136\/bcr-2020-236396","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T04:01:40Z","timestamp":1599624100000},"page":"e236396","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Rare case of <i>Ureaplasma parvum<\/i> septic arthritis in an immunocompetent patient"],"prefix":"10.1136","volume":"13","author":[{"given":"Abuzar Ali","family":"Asif","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-3405","authenticated-orcid":false,"given":"Moni","family":"Roy","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA"},{"name":"Department of Internal Medicine, OSF Saint Francis Medical Center, Peoria, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharjeel","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Infectious Diseases, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"2025082712572558000_13.9.e236396.1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.01965-0"},{"key":"2025082712572558000_13.9.e236396.2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1175-1179.2000"},{"key":"2025082712572558000_13.9.e236396.3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00963-14"},{"key":"2025082712572558000_13.9.e236396.4","doi-asserted-by":"crossref","first-page":"e307","DOI":"10.1016\/j.ijid.2010.02.2253","article-title":"Fatal outcome of a disseminated dual infection with drug-resistant Mycoplasma hominis and Ureaplasma parvum originating from a septic arthritis in an immunocompromised patient","volume":"14 Suppl 3","author":"MacKenzie","year":"2010","journal-title":"Int J Infect Dis"},{"key":"2025082712572558000_13.9.e236396.5","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-220383","article-title":"Ureaplasma parvum causing life-threatening disease in a susceptible patient","volume":"53","author":"Korytny","year":"2017","journal-title":"BMJ Case Rep"},{"key":"2025082712572558000_13.9.e236396.6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00432-14"},{"key":"2025082712572558000_13.9.e236396.7","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1097\/IPC.0000000000000752","article-title":"Identification of Ureaplasma parvum as a cause of culture-negative septic Monoarthitis using 16S rRNA gene sequencing","volume":"27","author":"Suknuntha","year":"2019","journal-title":"Infectious Diseases in Clinical Practice"},{"key":"2025082712572558000_13.9.e236396.8","first-page":"221","article-title":"Ureaplasma septic arthritis in an immunosuppressed patient with juvenile idiopathic arthritis","volume":"21","author":"George","year":"2015","journal-title":"JCR: Journal of Clinical Rheumatology"},{"key":"2025082712572558000_13.9.e236396.9","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw425"},{"key":"2025082712572558000_13.9.e236396.10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01439-12"},{"key":"2025082712572558000_13.9.e236396.11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01349-08"},{"key":"2025082712572558000_13.9.e236396.12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00889-15"},{"key":"2025082712572558000_13.9.e236396.13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00671-16"},{"key":"2025082712572558000_13.9.e236396.14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000323629","article-title":"In vitro activities of erythromycin, tetracycline and levofloxacin alone and in dual combinations against Ureaplasma spp","volume":"57","author":"Luo","year":"2011","journal-title":"Chemotherapy"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-236396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:57:34Z","timestamp":1756324654000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-236396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":14,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,8]]},"published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/bcr-2020-236396"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-236396","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}