{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:20:06Z","timestamp":1793643606114,"version":"4.5.1"},"reference-count":14,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,5]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Subacute sclerosing panencephalitis (SSPE) is a progressive lethal neurological inflammatory disease due to persistent, wild measles virus infection in the central nervous system that is seen most frequently in children and young adolescents. Atypical presentations are seen in up to 10% of cases. Most frequently and severely affected region in the brain is the parieto-occipital region of the brain. Less commonly involved organs are the cerebellum, basal ganglia and corpus callosum. Brainstem involvement is rare and usually occurs when other areas of brain are involved along with it. Here, we describe an unusual male patient of 15 years age, having SSPE with MRI of brain showing extensive involvement of brainstem with no significant involvement of other cortical structures of the brain. It is very rarely described in SSPE, but one should be vigilant about such involvement of brainstem and cerebellum, and SSPE should not be missed when brainstem hyperintensities are seen in MRI brain with or without other region of the brain to avoid misdiagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2020-236538","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T16:42:20Z","timestamp":1612456940000},"page":"e236538","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Subacute sclerosing panencephalitis and brain stem involvement: a rare combination"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-1307","authenticated-orcid":false,"given":"Heena","family":"Kathuria","sequence":"first","affiliation":[{"name":"Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"},{"name":"Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Prabhat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Shree","sequence":"additional","affiliation":[{"name":"Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7173-8035","authenticated-orcid":false,"given":"Rajveer","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"2025082623252478000_14.2.e236538.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0032-6"},{"key":"2025082623252478000_14.2.e236538.2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050323"},{"key":"2025082623252478000_14.2.e236538.3","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199707020-00003"},{"key":"2025082623252478000_14.2.e236538.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.07.003"},{"key":"2025082623252478000_14.2.e236538.5","doi-asserted-by":"publisher","DOI":"10.1016\/0387-7604(93)90120-W"},{"key":"2025082623252478000_14.2.e236538.6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.488"},{"key":"2025082623252478000_14.2.e236538.7","first-page":"761","article-title":"Subacute sclerosing panencephalitis: evaluation with CT and Mr","volume":"17","author":"Brismar","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082623252478000_14.2.e236538.8","first-page":"943","article-title":"MR imaging vs CT in subacute sclerosing panencephalitis","volume":"9","author":"Tsuchiya","year":"1988","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082623252478000_14.2.e236538.9","first-page":"542","article-title":"Brainstem involvement in subacute sclerosing panencephalitis","volume":"52","author":"Yarami\u015f","year":"2010","journal-title":"Turk J Pediatr"},{"key":"2025082623252478000_14.2.e236538.10","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmm020"},{"key":"2025082623252478000_14.2.e236538.11","first-page":"397","article-title":"Atypical neuroimaging findings with involvement of brainstem and cerebellum as well as basal ganglia in a case of SSPE misinterpreted as glioma","volume":"4","author":"Kalane","year":"2009","journal-title":"J Pediatr Neurol"},{"key":"2025082623252478000_14.2.e236538.12","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.79146"},{"key":"2025082623252478000_14.2.e236538.13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ejpn.2016.02.005","article-title":"Subacute sclerosing panencephalitis presenting as acute cerebellar ataxia and brain stem hyperintensities","volume":"20","author":"Saini","year":"2016","journal-title":"Eur J Paediatr Neurol"},{"key":"2025082623252478000_14.2.e236538.14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1177\/147323001103900228","article-title":"Epidemiological findings and clinical and magnetic resonance presentations in subacute sclerosing panencephalitis","volume":"39","author":"Cece","year":"2011","journal-title":"J Int Med Res"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-236538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:25:33Z","timestamp":1756275933000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-236538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,4]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-236538"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-236538","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}