{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:48:39Z","timestamp":1790102919321,"version":"4.0.1"},"reference-count":10,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,14]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Cytomegalovirus (CMV) can cause recalcitrant recurrent keratouveitis and secondary glaucoma. We report a case of chronic recurrent anterior uveitis with secondary glaucoma presenting with acute visual loss and interface fluid 9 years after laser in situ keratomileusis. Based on clinical presentation, a viral aetiology was suspected. Aqueous tap was positive for CMV-DNA by real-time quantitative PCR of the aqueous humour. The patient was treated with systemic antivirals, topical corticosteroids and antiglaucoma medications. The interface fluid resorbed rapidly. The intraocular pressure (IOP) was controlled by trabeculectomy. There was no further corneal deterioration at 7-month follow-up and the IOP had also stabilised. We believe this is only the third reported case of CMV-related interface fluid syndrome. This case highlights the role of quantitative PCR analysis for establishing viral aetiology in recurrent unilateral hypertensive anterior uveitis and reports the unusual finding of interface fluid which resolved after starting systemic antiviral therapy.<\/jats:p>","DOI":"10.1136\/bcr-2020-236742","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T11:30:11Z","timestamp":1619782211000},"page":"e236742","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Acute interface fluid syndrome after laser in situ keratomileusis in a case of cytomegalovirus (CMV) endotheliitis and secondary glaucoma"],"prefix":"10.1136","volume":"14","author":[{"given":"Sayali","family":"Tendolkar","sequence":"first","affiliation":[{"name":"Cornea and Anterior Segment Service, The Cornea Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-9669","authenticated-orcid":false,"given":"Somasheila I","family":"Murthy","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Service, The Cornea Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavya","family":"Chandran","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Service, The Cornea Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joveeta","family":"Joseph","sequence":"additional","affiliation":[{"name":"Jhaveri Microbiology Centre, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"2025082700590279000_14.4.e236742.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304625"},{"key":"2025082700590279000_14.4.e236742.2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.sjopt.2011.10.001","article-title":"Cytomegalovirus-related corneal endotheliitis: a review article","volume":"27","author":"Alfawaz","year":"2013","journal-title":"Saudi J Ophthalmol"},{"key":"2025082700590279000_14.4.e236742.3","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.jcrs.2006.03.040","article-title":"Interface fluid syndrome in laser in situ keratomileusis after complicated trabeculectomy","volume":"32","author":"Kang","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"2025082700590279000_14.4.e236742.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-013-0268-2"},{"key":"2025082700590279000_14.4.e236742.5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2005.08.049","article-title":"Uveitis-associated flap edema and lamellar interface fluid collection after LASIK","volume":"141","author":"Bacsal","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"2025082700590279000_14.4.e236742.6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-216774"},{"key":"2025082700590279000_14.4.e236742.7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4103\/0301-4738.64133","article-title":"Misleading Goldmann applanation tonometry in a post-LASIK eye with interface fluid syndrome","volume":"58","author":"Senthil","year":"2010","journal-title":"Indian J Ophthalmol"},{"key":"2025082700590279000_14.4.e236742.8","first-page":"S80","article-title":"High-resolution imaging of complicated LASIK flap interface fluid syndrome","volume":"39(4 Suppl)","author":"Ramos","year":"2008","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"2025082700590279000_14.4.e236742.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1813-7"},{"key":"2025082700590279000_14.4.e236742.10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/08820538.2014.959199","article-title":"Complications of glaucoma drainage device surgery: a review","volume":"29","author":"Giovingo","year":"2014","journal-title":"Semin Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-236742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:59:16Z","timestamp":1756281556000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-236742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,30]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2020-236742"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-236742","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}