{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:10:03Z","timestamp":1756307403447,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,20]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Incidental soft tissue lumps in the scalp are a common presenting complaint in clinical practice. However, they may signify more sinister underlying pathologies. Our report examines a 63-year-old man presenting with impaired co-ordination in his left hand following a 3-month history of a painless left retroauricular scalp lump. MRI revealed a large left occipital soft tissue mass eroding through the underlying skull with infiltration into the underlying cerebellum and temporal lobe. Open biopsy confirmed a diagnosis of high-grade intracranial neuroendocrine tumour (NET). At approximately 5 months following successful tumour resection and adjuvant chemotherapy, he developed tumour recurrence and was subsequently palliated, and died at 1 year post diagnosis. Herein, we review other cases of primary intracranial NET, clinical findings, histopathological features and prognosis.<\/jats:p>","DOI":"10.1136\/bcr-2020-236856","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T11:35:57Z","timestamp":1613993757000},"page":"e236856","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual cause of a painless soft tissue mass of the scalp: a rare presentation of primary intracranial neuroendocrine neoplasm"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-2073","authenticated-orcid":false,"given":"Susruta","family":"Manivannan","sequence":"first","affiliation":[{"name":"Neurosurgery, Southampton University Hospitals NHS Trust, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-3392","authenticated-orcid":false,"given":"Feras","family":"Sharouf","sequence":"additional","affiliation":[{"name":"School of Medicine, Cardiff University, Cardiff, UK"},{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Lammie","sequence":"additional","affiliation":[{"name":"School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Leach","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Wales, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"2025082707295146000_14.2.e236856.1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0014"},{"key":"2025082707295146000_14.2.e236856.2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0011"},{"key":"2025082707295146000_14.2.e236856.3","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-015-0514-y","article-title":"Large cell neuroendocrine carcinoma of the lung presenting as pseudoachalasia: a case report","volume":"9","author":"Anaizi","year":"2015","journal-title":"J Med Case Rep"},{"key":"2025082707295146000_14.2.e236856.4","doi-asserted-by":"crossref","DOI":"10.1186\/s12957-016-0887-4","article-title":"Primary intracranial neuroendocrine tumor: two case reports","volume":"14","author":"Liu","year":"2016","journal-title":"World J Surg Oncol"},{"key":"2025082707295146000_14.2.e236856.5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2478\/romneu-2013-0005","article-title":"Brain metastases of neuroendocrine tumor with unknown primary location - Case report","volume":"20","author":"Brehar","year":"2013","journal-title":"Romanian Neurosurgery"},{"key":"2025082707295146000_14.2.e236856.6","doi-asserted-by":"crossref","first-page":"e1013","DOI":"10.1016\/j.wneu.2017.07.053","article-title":"Pathologic progression, possible origin, and management of multiple primary intracranial neuroendocrine carcinomas","volume":"106","author":"Cao","year":"2017","journal-title":"World Neurosurg"},{"key":"2025082707295146000_14.2.e236856.7","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3171\/jns.2004.101.5.0858","article-title":"A carcinoid tumor mimicking an isolated intracranial meningioma. 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