{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:40:24Z","timestamp":1756280424898,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,10]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Alveolar soft part sarcoma (ASPS) is a rare malignant neoplasm that tends to occur in the deep soft tissues of both adults and children. ASPS has a progressive clinical course that is unfortunately characterised by late metastases and an overall poor prognosis. Although the tumour has been reported in a wide range of anatomic sites, few cases of primary laryngeal ASPS are reported in the literature. Here, we report the case of a 24-year-old man with no significant medical history who presented with progressive mild dysphonia and hoarseness. Imaging studies revealed a well-circumscribed, partially cystic submucosal mass with involvement of the right vocal fold and other local structures, and the patient was referred for surgical excision. Morphological and immunohistochemical examination of the excised lesion revealed ASPS. The findings of this case are compared with those of seven additional cases of primary laryngeal ASPS, which were found following literature review.<\/jats:p>","DOI":"10.1136\/bcr-2020-236867","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T13:56:29Z","timestamp":1610027789000},"page":"e236867","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Alveolar soft part sarcoma presenting in an unusual laryngeal location"],"prefix":"10.1136","volume":"14","author":[{"given":"Sylvia","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-6422","authenticated-orcid":false,"given":"Anthony","family":"Emanuel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Worley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2025082700022206000_14.1.e236867.1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195201)5:1<100::AID-CNCR2820050112>3.0.CO;2-K"},{"key":"2025082700022206000_14.1.e236867.2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.amjoto.2017.01.017","article-title":"Laryngeal alveolar soft part sarcoma: a case report of a rare malignancy in an atypical location","volume":"38","author":"Tamaki","year":"2017","journal-title":"Am J Otolaryngol"},{"key":"2025082700022206000_14.1.e236867.3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.031120"},{"key":"2025082700022206000_14.1.e236867.4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00405-006-0192-x","article-title":"Alveolar soft part sarcoma of the larynx","volume":"264","author":"Altu\u011f","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2025082700022206000_14.1.e236867.5","unstructured":"National Comprehensive Cancer Network . 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