{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:10:04Z","timestamp":1756311004024,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,4]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>We present a case of a 50-year-old man admitted due to acute abdomen, icterus and fever. The patient had a history of sufficiently treated type 2 diabetes and a high daily alcohol consumption, no recent travel history and had a strictly heterosexual and monogamous way of living. A full blood count displayed severe elevated liver enzymes. A CT of the abdomen was performed and revealed steatosis but no acute abdominal pathology. During admission, the patient developed signs of meningoencephalitis. A lumbar puncture was performed, and the cerebrospinal fluid revealed lymphocytic pleocytosis consistent with mild inflammation. Furthermore, hepatitis E was found in the blood and the definitive diagnosis was established. The patient gradually recovered and was discharged within 8 days of admission. To the best of our knowledge, we present the second case describing concomitant hepatitis and meningoencephalitis, resolving spontaneously and not giving rise to sequelae.<\/jats:p>","DOI":"10.1136\/bcr-2020-236922","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T23:30:27Z","timestamp":1607902227000},"page":"e236922","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Severe acute hepatitis E infection presenting with acute abdomen and meningoencephalitis"],"prefix":"10.1136","volume":"13","author":[{"given":"Rosa Maja M\u00f8hring","family":"Gynthersen","sequence":"first","affiliation":[{"name":"Infectious Diseases, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Philip","family":"R\u00f8nn","sequence":"additional","affiliation":[{"name":"Pulmonary and Infectious Diseases, Nordsj\u00e6llands Hospital, Hillerod, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Thomas","family":"Brandt","sequence":"additional","affiliation":[{"name":"Infectious Diseases, University Hospital Zealand, University of Copenhagen, Roskilde, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Mens","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,13]]},"reference":[{"key":"2025082708373495000_13.12.e236922.1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/jvh.13129","article-title":"Hepatitis E during pregnancy: maternal and foetal case-fatality rates and adverse outcomes-A systematic review","volume":"26","author":"Bergl\u00f8v","year":"2019","journal-title":"J Viral Hepat"},{"key":"2025082708373495000_13.12.e236922.2","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9020331","article-title":"Clinical manifestations, pathogenesis and treatment of hepatitis E virus infections","volume":"9","author":"Lhomme","year":"2020","journal-title":"J Clin Med"},{"key":"2025082708373495000_13.12.e236922.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.11.016"},{"key":"2025082708373495000_13.12.e236922.4","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1111\/trf.13028","article-title":"Declining prevalence of hepatitis E antibodies among Danish blood donors","volume":"55","author":"Holm","year":"2015","journal-title":"Transfusion"},{"key":"2025082708373495000_13.12.e236922.5","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282f5195a"},{"key":"2025082708373495000_13.12.e236922.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706992"},{"key":"2025082708373495000_13.12.e236922.7","doi-asserted-by":"publisher","DOI":"10.3201\/eid1712.110371"},{"key":"2025082708373495000_13.12.e236922.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.234"},{"key":"2025082708373495000_13.12.e236922.9","first-page":"1","article-title":"Extra-hepatic manifestations associated with hepatitis E virus infection: a comprehensive review of the literature","volume":"4","author":"Bazerbachi","year":"2016","journal-title":"Gastroenterol Rep"},{"key":"2025082708373495000_13.12.e236922.10","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/jac\/dky052","article-title":"Meningitis due to autochthonous acute infection with hepatitis E virus in a chef: a case report","volume":"73","author":"Rodr\u00edguez-Castro","year":"2018","journal-title":"J Antimicrob Chemother"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-236922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:37:46Z","timestamp":1756309066000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-236922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,13]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1136\/bcr-2020-236922"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-236922","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}