{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:40:02Z","timestamp":1756327202210,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,9]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Small cell lung cancer (SCLC) is a deadly and rapidly progressive disease that can present with various paraneoplastic syndromes on initial workup. Acquired factor VIII (FVIII) deficiency, also known as acquired haemophilia A (AHA), has been identified as a rare paraneoplastic syndrome in SCLC. Here, we present a 61-year-old woman with a massive gastrointestinal bleed and prolonged activated partial thromboplastin time (PTT) in the emergency department. She was diagnosed with rare paraneoplastic AHA secondary to extensive-stage SCLC (ES-SCLC). She was treated with high-dose steroids and factor bypassing agents, which led to the resolution of bleeding and undetectable FVIII inhibitor levels. She was subsequently treated for ES-SCLC with carboplatin, etoposide and atezolizumab. This case report highlights a rare clinical presentation of paraneoplastic AHA that necessitates prompt recognition in patients with SCLC with ongoing bleeding and elevated PTT.<\/jats:p>","DOI":"10.1136\/bcr-2020-236973","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T12:47:01Z","timestamp":1611838021000},"page":"e236973","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Paraneoplastic acquired haemophilia A in extensive-stage small cell lung cancer (ES-SCLC) in the era of immunotherapy"],"prefix":"10.1136","volume":"14","author":[{"given":"Mehrnoosh","family":"Pauls","sequence":"first","affiliation":[{"name":"Medical Oncology, University of Ottawa, Ottawa, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Rydz","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies, University of Calgary, Calgary, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A","family":"Nixon","sequence":"additional","affiliation":[{"name":"Medicine, University of Calgary, Calgary, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Ezeife","sequence":"additional","affiliation":[{"name":"Medical Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"2025082713110531000_14.1.e236973.1","unstructured":"Lung Health Foundation . 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