{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:01:47Z","timestamp":1781737307907,"version":"3.54.5"},"reference-count":13,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>A 59-year-old man with refractory Cronkhite-Canada syndrome (CCS) had poor clinical response to high-dose intravenous steroids, azathioprine, total parenteral nutrition and best supportive care. He remained highly symptomatic with abdominal pain, diarrhoea, recurrent sepsis and profound weight loss. Infliximab induction was given as rescue therapy, with marked clinical improvement observed within 3 weeks. This allowed steroid taper. Within 12 months of infliximab therapy, he achieved complete clinical remission and returned to his baseline weight and a full oral diet. Sequential endoscopies observed significant regression of previous marked gastrointestinal polyposis, including histological remission on colonic biopsies at 3.5 and 5 years of treatment. He currently remains in remission following 6 years of combination therapy with 5\u2009mg\/kg 8 weekly infliximab and azathioprine, and there is ongoing discussion with regard to the benefits and risks of therapy de-escalation. This case demonstrates the effectiveness of infliximab in inducing and maintaining remission in refractory CCS.<\/jats:p>","DOI":"10.1136\/bcr-2020-236990","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:18:21Z","timestamp":1608661101000},"page":"e236990","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Sustained clinical response to infliximab in refractory Cronkhite-Canada syndrome"],"prefix":"10.1136","volume":"13","author":[{"given":"Caroline Di","family":"Jiang","sequence":"first","affiliation":[{"name":"Gastroenterology, Wellington Hospital, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Myint","sequence":"additional","affiliation":[{"name":"Gastroenterology, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Tie","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, University of Otago, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel H","family":"Stace","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Otago, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"2025082708463175000_13.12.e236990.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195506162522401"},{"key":"2025082708463175000_13.12.e236990.2","first-page":"197","article-title":"A case of Cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes","volume":"8","author":"Seshadri","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"2025082708463175000_13.12.e236990.3","doi-asserted-by":"crossref","unstructured":"Yuan W , Tian L , Ai Fei\u2011Yan , et al . 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