{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:41:52Z","timestamp":1789674112004,"version":"4.0.1"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,9]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                  <jats:italic>Staphylococcus aureus<\/jats:italic> is a troublesome pathogen, responsible for a broad range of clinical manifestations, ranging from benign skin infections to life-threatening conditions such as endocarditis and osteomyelitis. The kidney can be affected through a rapidly progressive glomerulonephritis mediated by an inflammatory reaction against a superantigen deposited in the glomerulus during the infection\u2019s course. This glomerulopathy has a poor prognosis, often leading to chronically impaired kidney function, eventually progressing to end-stage renal disease. Treatment rests on antibiotherapy. Despite the inflammatory role in this disease\u2019s pathophysiology, most authors discourage a simultaneous immunosuppressive approach given the concomitant infection. However, there are some reports of success after administration of systemic corticosteroids in these patients. We present a 66-year-old man with a staphylococcus-induced glomerulonephritis brought on by a vascular graft infection, with rapidly deteriorating kidney function despite extraction of the infected graft and 3\u2009weeks of antibiotherapy with achievement of infection control. Kidney function improved after the introduction of corticosteroids. This case highlights the potential role of corticosteroids in selected cases of staphylococcus-induced glomerulonephritis, particularly those in which the infection is under control.<\/jats:p>","DOI":"10.1136\/bcr-2020-237011","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T12:33:55Z","timestamp":1611750835000},"page":"e237011","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Staphylococcus-induced glomerulonephritis: potential role for corticosteroids"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-5952","authenticated-orcid":false,"given":"Rui Filipe","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Nephrology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edtor","family":"Sousa","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal"},{"name":"Department of Pathology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"2025082800424311000_14.1.e237011.1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.407"},{"key":"2025082800424311000_14.1.e237011.2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199804)184:4<436::AID-PATH1225>3.0.CO;2-Y"},{"key":"2025082800424311000_14.1.e237011.3","unstructured":"Feehally J , Floege J , Tonelli M . Comprehensive clinical nephrology."},{"key":"2025082800424311000_14.1.e237011.4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.01.023"},{"key":"2025082800424311000_14.1.e237011.5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010060611"},{"key":"2025082800424311000_14.1.e237011.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2011.06.008"},{"key":"2025082800424311000_14.1.e237011.7","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.82141"},{"key":"2025082800424311000_14.1.e237011.8","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-007-9323-6"},{"key":"2025082800424311000_14.1.e237011.9","doi-asserted-by":"publisher","DOI":"10.5414\/CNP70344"},{"key":"2025082800424311000_14.1.e237011.10","first-page":"447","article-title":"IgA dominant postinfectious glomerulonephritis secondary to cutaneous infection by methicillin-resistant Staphylococcus aureus","volume":"39","author":"Carbayo","year":"2019","journal-title":"Nefrologia"},{"key":"2025082800424311000_14.1.e237011.11","doi-asserted-by":"crossref","unstructured":"Pestana N , Silva F , Vieira P , et al . IgA dominant glomerulonephritis associated to Staphylococcus infection: a peculiar case report. Pjnh 2019;33.doi:10.32932\/pjnh.2019.07.025","DOI":"10.32932\/pjnh.2019.07.025"},{"key":"2025082800424311000_14.1.e237011.12","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e318161b0fc"},{"key":"2025082800424311000_14.1.e237011.13","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05070516"},{"key":"2025082800424311000_14.1.e237011.14","first-page":"111","article-title":"Follow-up studies of three subtypes of acute postinfectious glomerulonephritis ascertained by renal biopsy","volume":"27","author":"Sorger","year":"1987","journal-title":"Clin Nephrol"},{"key":"2025082800424311000_14.1.e237011.15","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199503000-00001"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-237011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:42:48Z","timestamp":1756366968000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-237011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,27]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-237011"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-237011","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}