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Pathology of the cancerous lesions revealed neuroendocrine carcinoma. Gallbladder neuroendocrine tumours demonstrate no specific clinical features. Given its often late presentation, neuroendocrine tumours of the gallbladder pose a therapeutic and prognostic challenge.<\/jats:p>","DOI":"10.1136\/bcr-2020-237063","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:18:21Z","timestamp":1608661101000},"page":"e237063","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Silent and formidable foe: neuroendocrine tumours of the gallbladder"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-3818","authenticated-orcid":false,"given":"Darshan S","family":"Randhawa","sequence":"first","affiliation":[{"name":"Department of Surgery, MedStar Health, Columbia, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Shoucair","sequence":"additional","affiliation":[{"name":"Department of Surgery, MedStar Health, Columbia, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"McCarron","sequence":"additional","affiliation":[{"name":"Department of Surgery, MedStar Health, Columbia, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2025082802043343000_13.12.e237063.1","first-page":"601","article-title":"Neuroendocrine neoplasms of the appendix: a review of the literature","volume":"38","author":"Moris","year":"2018","journal-title":"Anticancer Res"},{"key":"2025082802043343000_13.12.e237063.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2009.08.002"},{"key":"2025082802043343000_13.12.e237063.3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canlet.2016.12.027","article-title":"Whole-Genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC)","volume":"391","author":"Li","year":"2017","journal-title":"Cancer Lett"},{"key":"2025082802043343000_13.12.e237063.4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/MCG.0b013e3181d7a6d4","article-title":"Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy","volume":"44","author":"Eltawil","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"2025082802043343000_13.12.e237063.5","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1016\/j.ijsu.2015.12.045","article-title":"\u2018Pure\u2019 large cell neuroendocrine carcinoma of the gallbladder","volume":"28","author":"Buscemi","year":"2016","journal-title":"Int J Surg"},{"key":"2025082802043343000_13.12.e237063.6","unstructured":"El Fattach H , Guerrache Y , Eveno C , et al . 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Carcinoid tumors. In: Schwartz AE , Pertsemlidis D , Gagner M , eds. Endocrine surgery. 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