{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:46:53Z","timestamp":1761965213522,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,16]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Hepatic brucelloma (HB), a rare manifestation of brucellosis, refers to liver involvement in the form of abscess. A 35-year-old woman stockbreeder was admitted due to 1-month history of evening fever, sweating and weight loss, while she was on 3-week course of rifampicin\/doxycycline for suspected brucellosis. On admission, she had hepatosplenomegaly and a systolic murmur, while cholestasis, increased inflammation markers and a strong-positive Wright-Coombs test were the main laboratory findings. As blood and bone marrow cultures were unrevealing, further investigation with CT imaging showed a central liver calcification surrounded by heterogeneous hypodense area being compatible with HB. Material from CT-guided drainage tested negative for <jats:italic>Brucella<\/jats:italic> spp. After failure to improve on a 10-week triple regiment, surgical excision was decided and <jats:italic>Brucella<\/jats:italic> spp were identified by PCR. Our case highlights challenges in establishing HB diagnosis, which should be considered on the right epidemiological context and when serological and radiological evidence favour its diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2020-237076","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T23:30:40Z","timestamp":1607902240000},"page":"e237076","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Hepatic brucelloma: a rare complication of a common zoonotic disease"],"prefix":"10.1136","volume":"13","author":[{"given":"George","family":"Vatidis","sequence":"first","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini I","family":"Rigopoulou","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Tepetes","sequence":"additional","affiliation":[{"name":"Department of Surgery, General University Hospital of Larissa, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-8464","authenticated-orcid":false,"given":"George N","family":"Dalekos","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,13]]},"reference":[{"key":"2025082702302589000_13.12.e237076.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050570"},{"key":"2025082702302589000_13.12.e237076.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70197-X"},{"key":"2025082702302589000_13.12.e237076.3","doi-asserted-by":"publisher","DOI":"10.1086\/319608"},{"key":"2025082702302589000_13.12.e237076.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)11090-4"},{"key":"2025082702302589000_13.12.e237076.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.03.008"},{"key":"2025082702302589000_13.12.e237076.6","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqn020"},{"key":"2025082702302589000_13.12.e237076.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.08.011"},{"key":"2025082702302589000_13.12.e237076.8","first-page":"315","article-title":"Leishmaniasis-associated haemophagocytic syndrome revisited: not an uncommon clinical presentation of leishmaniasis","volume":"3","author":"Saitis","year":"2012","journal-title":"J Med Cases"},{"key":"2025082702302589000_13.12.e237076.9","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-209387","article-title":"Spontaneous bacterial peritonitis: an unusual manifestation of brucellosis in a previous healthy male patient","volume":"2015","author":"Makaritsis","year":"2015","journal-title":"BMJ Case Rep"},{"key":"2025082702302589000_13.12.e237076.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.02.021"},{"key":"2025082702302589000_13.12.e237076.11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1515\/jtim-2015-0002","article-title":"Leishmaniasis revisited: current aspects on epidemiology, diagnosis and treatment","volume":"3","author":"Georgiadou","year":"2015","journal-title":"J Transl Int Med"},{"key":"2025082702302589000_13.12.e237076.12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.669-672.2006"},{"key":"2025082702302589000_13.12.e237076.13","doi-asserted-by":"crossref","DOI":"10.4076\/1757-1626-2-8125","article-title":"An immunocompetent patient presenting with severe septic arthritis due to Ralstonia pickettii identified by molecular-based assays: a case report","volume":"2","author":"Makaritsis","year":"2009","journal-title":"Cases J"},{"key":"2025082702302589000_13.12.e237076.14","unstructured":"Petinaki E , Cardiobacterium DGN . 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