{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:40:03Z","timestamp":1756366803794,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,10,11]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>A 65-year old man presented with 6-week history of bilateral knee pain and swelling, with difficulty mobilising. He had bilateral total knee arthroplasties in situ performed 5 years prior complicated by postoperative wound infection. Bilateral synovial fluid cultures were positive for <jats:italic>Abiotrophia defectiva<\/jats:italic>, and extensive investigations had not identified an extra-articular source of infection. Failing debridement antibiotic and implant retention procedure, the patient underwent a simultaneous bilateral 2-stage revision with articulated cement spacers impregnated with vancomycin and gentamycin. The patient received 6\u2009weeks of intravenous antibiotics after each stage. <jats:italic>A. defectiva<\/jats:italic> is a nutritiously fastidious organism, posing a challenge for clinical laboratories to isolate and perform antimicrobial susceptibility testing, yet prosthetic joint infections caused by <jats:italic>A. defectiva<\/jats:italic> are scarce in literature and present atypically with subacute signs of chronic infection. This poses a diagnostic and therapeutic challenge, and two-stage revision is the only documented treatment that successfully eradicates the infection.<\/jats:p>","DOI":"10.1136\/bcr-2020-237116","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T03:16:39Z","timestamp":1604459799000},"page":"e237116","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Simultaneous bilateral revision total knee arthroplasty following <i>Abiotrophia defectiva<\/i> infection"],"prefix":"10.1136","volume":"13","author":[{"given":"Joseph","family":"Wan","sequence":"first","affiliation":[{"name":"Trauma & Orthopaedics, Morriston Hospital, Swansea, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P","family":"Larsen","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics, Morriston Hospital, Swansea, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parag","family":"Panwalkar","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics, Morriston Hospital, Swansea, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Mofidi","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics, Morriston Hospital, Swansea, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.1","DOI":"10.1099\/00207713-45-4-798"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.2","DOI":"10.1128\/CMR.4.2.184"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.3","DOI":"10.1093\/eurheartj\/16.suppl_B.24"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.4","DOI":"10.1007\/s10096-004-1265-7"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.5","DOI":"10.1097\/SMJ.0b013e31817fe04c"},{"key":"2025082800240869000_13.11.e237116.6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.artd.2018.12.002","article-title":"Development of a periprosthetic joint infection by Abiotrophia defectiva years after total knee arthroplasty","volume":"5","author":"Tooley","year":"2019","journal-title":"Arthroplast Today"},{"key":"2025082800240869000_13.11.e237116.7","doi-asserted-by":"crossref","DOI":"10.1186\/1752-1947-5-438","article-title":"Abiotrophia defectiva knee prosthesis infection: a case report","volume":"5","author":"Cassir","year":"2011","journal-title":"J Med Case Rep"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.8","DOI":"10.1099\/0022-1317-51-10-899"},{"key":"2025082800240869000_13.11.e237116.9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.diagmicrobio.2010.11.016","article-title":"Abiotrophia defectiva infection of a total hip arthroplasty diagnosed by 16S rRNA gene sequencing","volume":"70","author":"Rozemeijer","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.10","DOI":"10.1128\/AAC.02645-15"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.11","DOI":"10.1016\/S0732-8893(00)00194-2"},{"doi-asserted-by":"publisher","key":"2025082800240869000_13.11.e237116.12","DOI":"10.1128\/JCM.02054-16"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-237116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:24:18Z","timestamp":1756365858000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-237116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,3]]},"published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1136\/bcr-2020-237116"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-237116","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}