{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:35:17Z","timestamp":1787960117135,"version":"build-2784847793"},"reference-count":11,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,10,22]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Long QT syndrome with Torsades de Pointes (TdP) is a life-threatening polymorphic ventricular arrhythmia. The corrected QT (QTc) prolongation &gt;500 milliseconds (ms) has been associated with TdP. Hypocalcaemia due to severe vitamin D deficiency is an uncommon cause of acquired long QT. We hereby present a case of a 40-year-old woman with sensorineural deafness and having symptoms of palpitations and presyncope. She had a QTc interval of 556 ms (reference range, QTc 451\u2013470 ms in adult healthy woman) on 24-hour Holter analysis. Genetic analysis for congenital long QT syndrome was negative. She was diagnosed with severe hypocalcaemia secondary to severe vitamin D deficiency. After treatment with intravenous calcium gluconate, followed by oral vitamin D and calcium supplementation, the QTc became normalised and no further episode of palpitations or presyncope occurred. The causes of vitamin D deficiency was due to inadequate exposure to sunlight and a strict vegan diet.<\/jats:p>","DOI":"10.1136\/bcr-2020-237157","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T17:40:35Z","timestamp":1608140435000},"page":"e237157","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Malignant prolongation of the QTc interval due to severe vitamin D deficiency: an unusual presentation"],"prefix":"10.1136","volume":"13","author":[{"given":"Preeti","family":"Gupta","sequence":"first","affiliation":[{"name":"Cardiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-5794","authenticated-orcid":false,"given":"Sourabh","family":"Agstam","sequence":"additional","affiliation":[{"name":"Cardiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Cardiology, Fortis Hospital Mohali, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-645X","authenticated-orcid":false,"given":"Soumitra","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Cardiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"2025082723440207000_13.12.e237157.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv695"},{"key":"2025082723440207000_13.12.e237157.2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960200318"},{"key":"2025082723440207000_13.12.e237157.3","first-page":"19","article-title":"Qt interval in human electrocardiogram in absence of cardiac disease","volume":"78","author":"Carter","year":"1922","journal-title":"JAMA"},{"key":"2025082723440207000_13.12.e237157.4","first-page":"132","article-title":"Torsade de pointes with severe vitamin D deficiency, an unusual presentation of a common problem","volume":"20","author":"Halawa","year":"2019","journal-title":"J Cardiol Cases"},{"key":"2025082723440207000_13.12.e237157.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192704"},{"key":"2025082723440207000_13.12.e237157.6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(57)90079-0"},{"key":"2025082723440207000_13.12.e237157.7","first-page":"656","article-title":"[Rare cardiac arrythmias of the pediatric age. ii. syncopal attacks due to paroxysmal ventricular fibrillation. (presentation of 1st case in italian pediatric literature)]","volume":"45","author":"Romano","year":"1963","journal-title":"Clin Pediatr"},{"key":"2025082723440207000_13.12.e237157.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2120"},{"key":"2025082723440207000_13.12.e237157.9","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104006134"},{"key":"2025082723440207000_13.12.e237157.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03423-9"},{"key":"2025082723440207000_13.12.e237157.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.283.6286.273"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-237157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:44:14Z","timestamp":1756363454000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-237157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":11,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,15]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1136\/bcr-2020-237157"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-237157","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}