{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:46Z","timestamp":1791229486122,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,26]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Altered mental status can have many causes ranging from emergent intracranial pathologies to more insidious, systemic toxic aetiologies. We report a rare case of dermato-neuro syndrome in a 71-year-old man with a known history of scleromyxoedema. The patient initially presented with encephalopathy which quickly progressed to generalised tonic\u2013clonic seizures and coma. While his presentation fits with other, although rare, cases of dermato-neuro syndrome, it is imperative to rule out lethal, more common causes of altered mentation. Due to the rarity and difficulty in diagnosis of dermato-neuro syndrome, there is a significant debate regarding the optimal management as there are no standardised treatment protocols. In our case, the patient was successfully treated with plasmapheresis resulting in improved neurologic function.<\/jats:p>","DOI":"10.1136\/bcr-2020-237170","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T11:59:16Z","timestamp":1609243156000},"page":"e237170","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Successful treatment of dermato-neuro syndrome with plasmapheresis"],"prefix":"10.1136","volume":"13","author":[{"given":"Jose Maciel","family":"Larios","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Providence-Providence Park Hospital, Southfield, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Ciuro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Providence-Providence Park Hospital, Southfield, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomson","family":"Sam Varghese","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Providence-Providence Park Hospital, Southfield, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Elizabeth","family":"Lyons","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, Providence Park Hospital, Novi, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"2025082712065258000_13.12.e237170.1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00362184","article-title":"Scleromyxedema: a strange manifestation of myxothesaurodermy","volume":"199","author":"Gottron","year":"1954","journal-title":"Arch Klin Exp 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