{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:44:14Z","timestamp":1792651454196,"version":"4.5.0"},"reference-count":18,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,8]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Solid pseudopapillary neoplasms (SPNs) are rare pancreatic cystic neoplasms occurring predominantly in young women and diagnosis is often a challenge. This report describes the case of a 23-year-old primigravida who presented with abnormally elevated liver blood tests at 24 weeks of gestation. Imaging studies were suggestive of SPN with metastatic liver disease. A multidisciplinary team approach decided on a preterm caesarean delivery of a healthy female child at 36 weeks of gestation. Subsequently, a CT-guided biopsy was performed, with confirmation of SPN in the anatomopathological study. Subpartial pancreatectomy, partial gastrectomy, cholecystectomy, total splenectomy and partial hepatectomy were successfully performed. A 3-month control CT scan and positron emission tomography-CT studies revealed disease recurrence with pulmonary and liver metastatic disease. The patient was started on a palliative chemotherapy protocol with good tolerance. To our knowledge this is the first case of a SPN described in pregnancy with distant metastasis and disseminated recurrence after surgical treatment.<\/jats:p>","DOI":"10.1136\/bcr-2020-237309","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T15:03:48Z","timestamp":1607526228000},"page":"e237309","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Solid pseudopapillary neoplasm of pancreas with distant metastasis during pregnancy: a diagnostic and treatment challenge"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-532X","authenticated-orcid":false,"given":"Diogo","family":"Santos","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Department, Hospital Doutor N\u00e9lio Mendon\u00e7a, Funchal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Calhau","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, Hospital Doutor N\u00e9lio Mendon\u00e7a, Funchal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Bacelar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, Hospital Doutor N\u00e9lio Mendon\u00e7a, Funchal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Vieira","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, Hospital Doutor N\u00e9lio Mendon\u00e7a, Funchal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"2025082622444568000_13.12.e237309.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0195-x"},{"key":"2025082622444568000_13.12.e237309.2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4253\/wjge.v10.i9.145","article-title":"Clinical update on the management of pseudopapillary tumor of pancreas","volume":"10","author":"Lanke","year":"2018","journal-title":"World J Gastrointest Endosc"},{"key":"2025082622444568000_13.12.e237309.3","first-page":"1","article-title":"Management of a pregnancy with a solid pseudopapillary neoplasm of the pancreas","volume":"2018","author":"Tanacan","year":"2018","journal-title":"Case Rep Obstet Gynecol"},{"key":"2025082622444568000_13.12.e237309.4","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gou006"},{"key":"2025082622444568000_13.12.e237309.5","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.4103\/njcp.njcp_39_18","article-title":"Solid pseudopapillary neoplasm of pancreas in pregnancy treated with tumor enucleation: case report and review of the literature","volume":"21","author":"Huang","year":"2018","journal-title":"Niger J Clin Pract"},{"key":"2025082622444568000_13.12.e237309.6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s12253-019-00671-8","article-title":"Solid-pseudopapillary neoplasms of the pancreas is still an enigma: a clinicopathological review","volume":"26","author":"Zalatnai","year":"2020","journal-title":"Pathol Oncol Res"},{"key":"2025082622444568000_13.12.e237309.7","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjv108","article-title":"Solid pseudopapillary neoplasm of the pancreas head in a pregnant woman: safe pancreaticoduodenectomy postpartum","volume":"2015","author":"Yee","year":"2015","journal-title":"J Surg Case Rep"},{"key":"2025082622444568000_13.12.e237309.8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/AOG.0000000000002748","article-title":"Nonobstetric surgery during pregnancy","volume":"132","author":"Tolcher","year":"2018","journal-title":"Obstet Gynecol"},{"key":"2025082622444568000_13.12.e237309.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80182-4"},{"key":"2025082622444568000_13.12.e237309.10","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770139"},{"key":"2025082622444568000_13.12.e237309.11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF02788425","article-title":"Papillary-cystic neoplasm of the pancreas. 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