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Initial investigations including blood tests and brain imaging did not reveal the diagnosis. The patient developed an increasing frequency of abnormal movements of her face and arm. These were clinically recognised as faciobrachial dystonic seizures (FBDS). FBDS are pathognomonic of an autoimmune encephalitis caused by an antibody directed against leucine-rich glioma-inactivated 1 (LGI1). The clinical diagnosis resulted in treatment with immunotherapy, leading to cessation of seizures and rapid cognitive recovery. Later, the predicted serology was confirmed. This reversible and under-recognised cause of cognitive impairment, typically affecting elderly patients, can be diagnosed clinically to enable early and effective treatment.<\/jats:p>","DOI":"10.1136\/bcr-2020-237398","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T18:45:27Z","timestamp":1610477127000},"page":"e237398","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical diagnosis of LGI1 antibody encephalitis in an 83-year-old woman"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-4077","authenticated-orcid":false,"given":"Jonathan E","family":"Attwood","sequence":"first","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK"},{"name":"Department of Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, 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