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Although rare, DRESS syndrome triggered by specific agents has been associated with specific genetic polymorphisms more prevalent in different ethnic groups, including an association between dapsone-induced DRESS and Human Leukocyte Antigen (HLA)-B:13*01, a single nucleotide polymorphism more prevalent in those of Asian descent. DRESS and drug-related vasculitis may affect any organ system including the central nervous system (CNS), usually manifesting as encephalitis, meningitis or embolic cerebrovascular accidents related to eosinophilic cardiac disease and thrombosis. CNS vasculitis is a much rarer complication of drug reactions that may manifest as multifocal ischemia on neuroimaging. In circumstances of drug-related vasculitides, treatment with high-dose corticosteroids may lead to rapid improvement and, ultimately, resolution of associated focal neurologic deficits.<\/jats:p>","DOI":"10.1136\/bcr-2020-237560","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:12:54Z","timestamp":1678752774000},"page":"e237560","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Dapsone-induced DRESS after infliximab-induced vasculitis: a case of cerebral infarction in the context of multiple drug reactions"],"prefix":"10.1136","volume":"13","author":[{"given":"Michael","family":"Roth","sequence":"first","affiliation":[{"name":"Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery T","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-6896","authenticated-orcid":false,"given":"Paul Gabriel","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"2025082713031179000_13.12.e237560.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.033"},{"key":"2025082713031179000_13.12.e237560.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"2025082713031179000_13.12.e237560.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213096"},{"key":"2025082713031179000_13.12.e237560.4","first-page":"301","article-title":"Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms","volume":"137","author":"Descamps","year":"2001","journal-title":"Arch Dermatol"},{"key":"2025082713031179000_13.12.e237560.5","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00234-015-1562-0","article-title":"Dress syndrome: cerebral vasculitic-like presentation","volume":"57","author":"Gaha","year":"2015","journal-title":"Neuroradiology"},{"key":"2025082713031179000_13.12.e237560.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08167.x"},{"key":"2025082713031179000_13.12.e237560.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2015.01.006"},{"key":"2025082713031179000_13.12.e237560.8","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s10072-014-1814-5","article-title":"Acute cerebral infarction in watershed distribution in a patient with hypereosinophilic syndrome without cardiac lesion","volume":"35","author":"Wu","year":"2014","journal-title":"Neurol Sci"},{"key":"2025082713031179000_13.12.e237560.9","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s00415-015-7720-9","article-title":"Idiopathic hypereosinophilic syndrome: a new cause of vasculitis of the central nervous system","volume":"262","author":"Rice","year":"2015","journal-title":"J Neurol"},{"key":"2025082713031179000_13.12.e237560.10","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2169\/internalmedicine.52.8762","article-title":"Dress syndrome with cerebral vasculitis","volume":"52","author":"Sola","year":"2013","journal-title":"Intern Med"},{"key":"2025082713031179000_13.12.e237560.11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.6.2025"},{"key":"2025082713031179000_13.12.e237560.12","unstructured":"Kasper DL , Hauser SL , Jameson JL , et al . 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