{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:10:03Z","timestamp":1756282203005,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Cholangiocarcinomas are rare and often diagnosed late. Clear cell histology is a rare variant of such cancers. We report one such case of a man in his late 60s, with a history of excess alcohol intake, who was found to have deranged liver biochemical tests incidentally during an admission for an allergic reaction. Subsequent imaging to investigate this suggested a diagnosis of perihilar cholangiocarcinoma (ultrasound, CT, MRI, cholangiogram). Biopsy confirmed this to be of clear cell type on histology and immunohistochemistry. Diagnosis and further management of this rare entity was conducted in multidisciplinary meetings with the regional hepatobiliary centre. The patient was deemed unsuitable for surgical resection, underwent chemotherapy but died 1\u2009year later.<\/jats:p>","DOI":"10.1136\/bcr-2020-237683","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:18:21Z","timestamp":1608661101000},"page":"e237683","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Perihilar clear cell cholangiocarcinoma: an often-diagnostic challenge"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-2839","authenticated-orcid":false,"given":"Omar","family":"Marzouk","sequence":"first","affiliation":[{"name":"Department of Surgery, Queen Elizabeth the Queen Mother Hospital, Margate, Kent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddappa","family":"Lakshmaiah","sequence":"additional","affiliation":[{"name":"Department of Radiology, Queen Elizabeth the Queen Mother Hospital, Margate, Kent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Anjarwalla","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, William Harvey Hospital, Ashford, Kent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2025082700435414000_13.12.e237683.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.51"},{"key":"2025082700435414000_13.12.e237683.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90178-6"},{"key":"2025082700435414000_13.12.e237683.3","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199610000-00005"},{"key":"2025082700435414000_13.12.e237683.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61903-0"},{"key":"2025082700435414000_13.12.e237683.5","doi-asserted-by":"crossref","unstructured":"Zimmermann A . Hilar\/Perihilar cholangiocarcinoma. In: Tumors and tumor-like lesions of the hepatobiliary tract. General and surgical pathology. 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Case report and literature review","volume":"97","author":"Gu","year":"2018","journal-title":"Medicine"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-237683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:44:06Z","timestamp":1756280646000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-237683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":13,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,22]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1136\/bcr-2020-237683"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-237683","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}