{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:02:49Z","timestamp":1773248569677,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,26]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>SARS-CoV-2 is the cause of COVID-19. Since the outbreak and rapid spread of COVID-19, it has been apparent that the disease is having multi-organ system involvement. Still its effect in the endocrine system is not fully clear and data on cortisol dynamics in patients with COVID-19 are not yet available. SARS-CoV-2 can knock down the host\u2019s cortisol stress response. Here we present a case of a 51-year-old man vomiting for 10 days after having confirmed COVID-19 infection. He had hypotension and significant hyponatraemia. Work-up was done including adrenocorticotropic hormone stimulation test. He was diagnosed as suffering from adrenal insufficiency and started on steroids with subsequent improvement in both blood pressure and sodium level. COVID-19 can cause adrenal insufficiency. Clinicians must be vigilant about the possibility of an underlying relative cortisol deficiency in patients with COVID-19.<\/jats:p>","DOI":"10.1136\/bcr-2020-237690","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T12:07:55Z","timestamp":1610971675000},"page":"e237690","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["New onset adrenal insufficiency in a patient with COVID-19"],"prefix":"10.1136","volume":"14","author":[{"given":"Maram","family":"Hashim","sequence":"first","affiliation":[{"name":"Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Athar","sequence":"additional","affiliation":[{"name":"Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-3901","authenticated-orcid":false,"given":"Waqar Haider","family":"Gaba","sequence":"additional","affiliation":[{"name":"Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2025082707115538000_14.1.e237690.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0353-9"},{"key":"2025082707115538000_14.1.e237690.2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s12020-020-02325-1","article-title":"COVID-19, hypothalamo-pituitary-adrenal axis and clinical implications","volume":"68","author":"Pal","year":"2020","journal-title":"Endocrine"},{"key":"2025082707115538000_14.1.e237690.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.04.009"},{"key":"2025082707115538000_14.1.e237690.4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s40618-020-01276-8","article-title":"COVID-19 and the endocrine system: exploring the unexplored","volume":"43","author":"Pal","year":"2020","journal-title":"J Endocrinol Invest"},{"key":"2025082707115538000_14.1.e237690.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02325.x"},{"key":"2025082707115538000_14.1.e237690.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30317-2"},{"key":"2025082707115538000_14.1.e237690.7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2422"},{"key":"2025082707115538000_14.1.e237690.8","unstructured":"Chinese Clinical Trial Register. Wuhan (Hubei): Ministry of Health (China) . Identifier ChiCTR2000030115. A clinical research for the changes of blood cortisol ACTH level and adrenal morphology in blood cortisol to guide the application of individualized hormone in severe novel coronavirus pneumonia (COVID-19) patients, 2020. Available: http:\/\/www.chictr.org.cn"},{"key":"2025082707115538000_14.1.e237690.9","doi-asserted-by":"publisher","DOI":"10.1259\/bjrcr.20200075"},{"key":"2025082707115538000_14.1.e237690.10","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1210\/clinem\/dgaa487","article-title":"Bilateral adrenal hemorrhage in coronavirus disease 2019 patient: a case report","volume":"105","author":"Frankel","year":"2020","journal-title":"J Clin Endocrinol Metab"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-237690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:12:05Z","timestamp":1756303925000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-237690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-237690"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-237690","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}