{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:17:07Z","timestamp":1756383427445,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,2,26]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a relatively rare condition in Australia. Here, we report a case of PTCL, NOS in a patient who presented with persistent fever and progressive pancytopenia on a background of mediastinal lymphadenopathy, initially presumed reactive and hepatosplenomegaly with deranged liver function tests. The diagnosis was challenging, with multiple negative blood cultures and inconclusive bone marrow studies, and it required extensive investigations that ultimately revealed the characteristic clinical, histopathological and immunophenotypic features of PTCL, NOS. The patient underwent multiple rounds of multiagent chemotherapy after the diagnosis. This case highlights the difficulty in diagnosing PTCL, NOS and the importance of including it as a differential diagnosis in younger patients who present with constitutional symptoms and hepatosplenomegaly.<\/jats:p>","DOI":"10.1136\/bcr-2020-237806","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T11:55:19Z","timestamp":1615377319000},"page":"e237806","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral T-cell lymphoma presenting as fever of unknown origin in a man with deranged liver function tests and pancytopenia"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-4935","authenticated-orcid":false,"given":"Catharine","family":"McKay","sequence":"first","affiliation":[{"name":"Medicine, Central Gippsland Health Service, Sale, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Tse","family":"Hong","sequence":"additional","affiliation":[{"name":"Medicine Department, Central Gippsland Health Service, Sale, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9836-4093","authenticated-orcid":false,"given":"A K M Nizam","family":"Uddin","sequence":"additional","affiliation":[{"name":"Monash Lung & Sleep, Central Gippsland Health Service, Sale, Victoria, Australia"},{"name":"Lung & Sleep, Monash Medical Centre Clayton, Clayton, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"2025082804305564000_14.3.e237806.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.07.010"},{"key":"2025082804305564000_14.3.e237806.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-231548"},{"key":"2025082804305564000_14.3.e237806.3","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.humpath.2015.03.002","article-title":"Epstein-Barr virus-positive nodal T\/NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features","volume":"46","author":"Jeon","year":"2015","journal-title":"Hum Pathol"},{"key":"2025082804305564000_14.3.e237806.4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/hon.2203","article-title":"Peripheral T-cell lymphoma with unusual clinical presentation of rhabdomyolysis","volume":"35","author":"Liu","year":"2017","journal-title":"Hematol Oncol"},{"key":"2025082804305564000_14.3.e237806.5","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.2169\/internalmedicine.51.7457","article-title":"Sub-Acute demyelinating polyradiculoneuropathy as an initial symptom of peripheral T cell lymphoma, not otherwise specified (PTCL-NOS)","volume":"51","author":"Kawanishi","year":"2012","journal-title":"Intern Med"},{"key":"2025082804305564000_14.3.e237806.6","first-page":"1-16","article-title":"Peripheral T-cell lymphoma: a case-based discussion of recent advances in patient management","volume":"9","author":"Franco","year":"2011","journal-title":"Clin Adv Hematol Oncol"},{"key":"2025082804305564000_14.3.e237806.7","doi-asserted-by":"crossref","unstructured":"Singh A , Bhagat M , Siddiqui AD , et al . Peripheral T-cell lymphoma, not otherwise specified: an unusual presentation of a rare lymphoma. 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