{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:49:48Z","timestamp":1772628588512,"version":"3.50.1"},"reference-count":42,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,8,25]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>SARS-CoV-2, the virus responsible for COVID-19, binds to the ACE2 receptors. ACE2 is thought to counterbalance ACE in the renin-angiotensin system. While presently it is advised that patients should continue to use ACE inhibitors or angiotensin receptor blockers, questions still remain as to whether adverse effects are potentiated by the virus. Here, we report a case of a 57-year-old man, unknowingly with COVID-19, who presented to the emergency department with tongue swelling, shortness of breath and difficulty in speaking following 4 months taking benazepril, an ACE inhibitor. Finally, we also describe possible pathways that exist for SARS-CoV-2 to interact with the mechanism behind angioedema.<\/jats:p>","DOI":"10.1136\/bcr-2020-237888","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T03:39:42Z","timestamp":1599709182000},"page":"e237888","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Angioedema, ACE inhibitor and COVID-19"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6073-6296","authenticated-orcid":false,"given":"Ekjot","family":"Grewal","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Brookdale University Hospital Medical Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayu","family":"Sutarjono","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Brookdale University Hospital Medical Center, Brooklyn, New York, USA"},{"name":"Saba University School of Medicine, Devens, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibbad","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Brookdale University Hospital Medical Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"2025082702123883000_13.9.e237888.1","first-page":"30183","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"6736","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"2025082702123883000_13.9.e237888.2","unstructured":"Joint mission report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19). 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Latest data support continued use of ACE inhibitors and ARB medicines during COVID-19 pandemic. European medicines agency: science medicines health, 2020. Available: https:\/\/www.ema.europa.eu\/en\/news\/latest-data-support-continued-use-ace-inhibitors-arb-medicines-during-covid-19-pandemic"},{"key":"2025082702123883000_13.9.e237888.42","unstructured":"National Institutes of Health . Considerations for certain concomitant medications in patients with COVID-19. NIH: COVID-19 treatment guidelines, 2020. 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