{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:41:37Z","timestamp":1761745297035,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,9,18]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Early case series suggest that about one-third of patients with COVID-19 present with neurological manifestations, including cerebrovascular disease, reported in 2%\u20136% of hospitalised patients. These are generally older patients with severe infection and comorbidities. Here we discuss the case of a previously fit and well 39-year-old man who presented with fever and respiratory symptoms, evolving in pneumonia with hypoxia but only requiring continuous positive airway pressure. After resolution of the respiratory disease, the patient developed focal neurology and was found to have bilateral occipital, thalamic and cerebellar infarcts. A diagnosis of COVID-19 central nervous system vasculopathy was made. He developed a florid neuropsychiatric syndrome, including paranoia, irritability, aggression and disinhibition, requiring treatment with antipsychotics and transfer to neurorehabilitation. Neuropsychometry revealed a wide range of cognitive deficits. The rapid evolution of the illness was matched by fast resolution of the neuropsychiatric picture with mild residual cognitive impairment.<\/jats:p>","DOI":"10.1136\/bcr-2020-237926","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T17:35:12Z","timestamp":1602783312000},"page":"e237926","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Possible affective cognitive cerebellar syndrome in a young patient with COVID-19 CNS vasculopathy and stroke"],"prefix":"10.1136","volume":"13","author":[{"given":"Kai Xin","family":"Chia","sequence":"first","affiliation":[{"name":"Blackheath Brain Injury Rehabilitation Centre, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Polakhare","sequence":"additional","affiliation":[{"name":"Blackheath Brain Injury Rehabilitation Centre, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania Dafne","family":"Bruno","sequence":"additional","affiliation":[{"name":"Blackheath Brain Injury Rehabilitation Centre, London, UK"},{"name":"IOPPN, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"2025082708191070000_13.10.e237926.1","unstructured":"Transmission of SARS-CoV-2: implications for infection prevention precautions. 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SARS-CoV-2 infectivity and neurological targets in the brain. 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Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to D-dimer levels. Radiology 2020:201561."},{"key":"2025082708191070000_13.10.e237926.22","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"2025082708191070000_13.10.e237926.23","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25829"},{"key":"2025082708191070000_13.10.e237926.24","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14810"},{"key":"2025082708191070000_13.10.e237926.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(98)90051-X"},{"key":"2025082708191070000_13.10.e237926.26","unstructured":"Randolph C . Repeatable battery for the assessment of neuropsychological status, RBANS update. 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