{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:28:32Z","timestamp":1761845312162,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,5]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>\n                  <jats:italic>Enterococcus hirae<\/jats:italic>, a member of the <jats:italic>Enterococcus<\/jats:italic> genus, is known to cause infections, including infective endocarditis (IE), in animal species. In humans, <jats:italic>E. hirae<\/jats:italic> is an uncommon pathogen, but has been associated with severe and recurrent disease. Here, we report the first Danish case of <jats:italic>E. hirae<\/jats:italic> native aortic valve IE in a 62-year-old woman with no history of heart disease. She presented to the hospital with symptoms of gastroenteritis but no signs of heart disease. Nevertheless, blood culture revealed growth of <jats:italic>E. hirae<\/jats:italic>, and a transoesophageal echocardiography demonstrated a mobile mass adherent to the aortic valve, compatible with a vegetation. The patient was successfully treated for <jats:italic>E. hirae<\/jats:italic> native aortic valve IE with 4\u2009weeks of intravenous benzylpenicillin in combination with gentamicin for the initial 2\u2009weeks. To the best of our knowledge, this is the first documented case of <jats:italic>E. hirae<\/jats:italic> IE in Denmark and the sixth documented case worldwide.<\/jats:p>","DOI":"10.1136\/bcr-2020-237950","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:18:21Z","timestamp":1608661101000},"page":"e237950","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["First Danish case of infective endocarditis caused by <i>Enterococcus hirae<\/i>"],"prefix":"10.1136","volume":"13","author":[{"given":"Mette","family":"Winther","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Aalborg University hospital, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dalager-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene Harder","family":"Tarpgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aalborg University hospital, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-417X","authenticated-orcid":false,"given":"Hans Linde","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aalborg University hospital, Aalborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2025082722554826000_13.12.e237950.1","doi-asserted-by":"crossref","unstructured":"Carroll KC PM , Landry ML , McAdam AJ . 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