{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:59:27Z","timestamp":1781629167464,"version":"3.54.5"},"reference-count":8,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,6,25]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>A 52-year-old male patient with polyarthritis nodosa (PAN) was referred to our neurology outpatient clinic. His main symptom was paroxysmal alternating bilateral blindness. Subsequently, he developed retro-orbital pain. Neurological examination including funduscopy was normal and laboratory tests showed no relevant abnormalities. MRI orbits showed remarkable perineural thickening and contrast enhancement of the optic nerve sheaths with sparing of the central optic nerve. These findings are pathognomonic for the clinical-radiological diagnosis of optic perineuritis (OPN). The patient was treated with high-dose immunosuppressants and had a good clinical outcome. Rapid diagnosis of OPN is important because early treatment is associated with a better outcome.<\/jats:p>","DOI":"10.1136\/bcr-2020-237988","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T12:56:10Z","timestamp":1626872170000},"page":"e237988","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Optic perineuritis in polyarthritis nodosa"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-5933","authenticated-orcid":false,"given":"Sijgje Maria","family":"Droger","sequence":"first","affiliation":[{"name":"Neurology, Maasstad Hospital, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Hein","family":"Hensen","sequence":"additional","affiliation":[{"name":"Radiology, Maasstad Hospital, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Cornelis","family":"van Rooij","sequence":"additional","affiliation":[{"name":"Neurology, Maasstad Hospital, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"2025082722003724000_14.7.e237988.1","first-page":"181","article-title":"Optic perineuritis: a retrospective case series","volume":"10","author":"Bergman","year":"2017","journal-title":"Int Med Case Rep J"},{"key":"2025082722003724000_14.7.e237988.2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1001\/archopht.119.9.1299","article-title":"Optic perineuritis: clinical and radiographic features","volume":"119","author":"Purvin","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"2025082722003724000_14.7.e237988.3","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101206010065"},{"key":"2025082722003724000_14.7.e237988.4","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1442-9071.2009.02122.x","article-title":"Optic perineuritis secondary to Wegener\u2019s granulomatosis","volume":"37","author":"Purvin","year":"2009","journal-title":"Clin Experiment Ophthalmol"},{"key":"2025082722003724000_14.7.e237988.5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/WNO.0000000000000717","article-title":"Optic perineuritis due to tuberculosis","volume":"39","author":"Yates","year":"2019","journal-title":"J Neuroophthalmol"},{"key":"2025082722003724000_14.7.e237988.6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/WNO.0000000000000822","article-title":"Isolated optic perineuritis as the presenting sign of sarcoidosis","volume":"40","author":"Micieli","year":"2020","journal-title":"J Neuroophthalmol"},{"key":"2025082722003724000_14.7.e237988.7","unstructured":"Merkel PA . Manifestations and diagnosis of polyarteritis nodosa in adults. Hunder GG ED. UpToDate Inc. Available: https:\/\/www.uptodate.com\/contents\/clinical-manifestations-and-diagnosis-of-polyarteritis-nodosa-in-adults?search=polyarteritis%20nodosa%20adult&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1 [Accessed 14 Oct 2019]."},{"key":"2025082722003724000_14.7.e237988.8","doi-asserted-by":"crossref","DOI":"10.1007\/s11910-015-0617-2","article-title":"Optic perineuritis","volume":"16","author":"Hickman","year":"2016","journal-title":"Curr Neurol Neurosci Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-237988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:00:43Z","timestamp":1756357243000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-237988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":8,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,21]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2020-237988"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-237988","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}