{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:10:15Z","timestamp":1756375815182,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,10,13]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Malignant peripheral nerve sheath tumours (MPNSTs) are tumours that arise from or differentiate towards cells of the peripheral nerve sheath. They are extremely rare with an incidence of 0.001% in the general population. The most common association is with neurofibromatosis 1\u2014an incidence of 5%\u201342% in this subset of the population is quoted in the literature. These tumours are aggressive with a high rate of local recurrence. Complete surgical excision remains the mainstay of treatment. A literature search found only three case reports of MPNSTs originating in the salivary glands\u2014in all other cases the parotid gland. We present here the first documented case of a patient presented with an MPNST of the submandibular gland managed surgically by a specialty centre.<\/jats:p>","DOI":"10.1136\/bcr-2020-238110","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T15:46:31Z","timestamp":1606751191000},"page":"e238110","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Malignant peripheral nerve sheath tumour arising in the submandibular gland"],"prefix":"10.1136","volume":"13","author":[{"given":"Muhammad Ibaad ur rehman","family":"Alvi","sequence":"first","affiliation":[{"name":"CST, Manchester Royal Infirmary, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Pilkington","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raguwinder S","family":"Sahota","sequence":"additional","affiliation":[{"name":"ENT\/Head and Neck Surgery, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Adams","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"2025082802394507000_13.11.e238110.1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2007.22.3.1"},{"key":"2025082802394507000_13.11.e238110.2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196308)16:8<1015::AID-CNCR2820160808>3.0.CO;2-I"},{"key":"2025082802394507000_13.11.e238110.3","first-page":"1573","article-title":"International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis","volume":"62","author":"Ferner","year":"2002","journal-title":"Cancer Res"},{"key":"2025082802394507000_13.11.e238110.4","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/014556130608500620","article-title":"Malignant peripheral nerve sheath tumors of the head and neck: two cases and a review of the literature","volume":"85","author":"Martinez Devesa","year":"2006","journal-title":"Ear Nose Throat J"},{"key":"2025082802394507000_13.11.e238110.5","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200711"},{"key":"2025082802394507000_13.11.e238110.6","first-page":"455","article-title":"[Malignant schwannoma of parotid gland. Case report and review of literature]","volume":"54","author":"Skorek","year":"2000","journal-title":"Otolaryngol Pol"},{"key":"2025082802394507000_13.11.e238110.7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6"},{"key":"2025082802394507000_13.11.e238110.8","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.02870.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:39:54Z","timestamp":1756373994000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1136\/bcr-2020-238110"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238110","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}