{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:29:52Z","timestamp":1770416992520,"version":"3.49.0"},"reference-count":12,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,30]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Renal involvement in mantle cell lymphoma (MCL) is rare. We present the case of a man followed for MCL presented with acute kidney injury and positive antineutrophil cytoplasmic antibody (ANCA) type anti proteinase 3 (PR3). He was treated as for a rapidly progressing glomerulonephritis with cyclophosphamide and methylprednisolone followed by oral prednisone. Renal biopsy revealed diffuse endocapillary proliferation and segmental extracapillary proliferation in four glomeruli. Immunohistochemistry confirmed the renal invasion of lymphomatous cells. He started improving his renal function shortly after starting treatment. The coexistence of renal MCL infiltration, extracapillary proliferation and ANCA positive is exceptional.<\/jats:p>","DOI":"10.1136\/bcr-2020-238153","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T15:56:42Z","timestamp":1612540602000},"page":"e238153","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Proliferative glomerulonephritis and mantle cell lymphoma: a rare association"],"prefix":"10.1136","volume":"14","author":[{"given":"Bilel","family":"Mhedhbi","sequence":"first","affiliation":[{"name":"Internal Medecine Department, Charles Nicolle Hospital, Bab Saadoun, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5717-3875","authenticated-orcid":false,"given":"Soumaya","family":"Chargui","sequence":"additional","affiliation":[{"name":"Internal Medecine Department, Charles Nicolle Hospital, Bab Saadoun, Tunis, Tunisia"},{"name":"Research Laboratory of Renal Pathology LR00SP01, Charles Nicolle Hospital, Bab Saadoun, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Harzallah","sequence":"additional","affiliation":[{"name":"Internal Medecine Department, Charles Nicolle Hospital, Bab Saadoun, Tunis, Tunisia"},{"name":"Research Laboratory of Renal Pathology LR00SP01, Charles Nicolle Hospital, Bab Saadoun, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rim","family":"Goucha","sequence":"additional","affiliation":[{"name":"Research Laboratory of Renal Pathology LR00SP01, Charles Nicolle Hospital, Bab Saadoun, Tunis, Tunisia"},{"name":"Nephrology department, University Hospital Center Mongi Slim, La Marsa, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"2025082700190164000_14.2.e238153.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.07.004"},{"key":"2025082700190164000_14.2.e238153.2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0140-6736(90)92755-7","article-title":"'False-positive' anti-neutrophil cytoplasmic antibodies in HIV infection","volume":"335","author":"Koderisch","year":"1990","journal-title":"Lancet"},{"key":"2025082700190164000_14.2.e238153.3","first-page":"153","article-title":"Anti-Neutrophil cytoplasm antibodies in patients with monoclonal gammopathies","volume":"32","author":"Esnault","year":"1990","journal-title":"J Clin Lab Immunol"},{"key":"2025082700190164000_14.2.e238153.4","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<226::AID-ANR27>3.0.CO;2-Q"},{"key":"2025082700190164000_14.2.e238153.5","first-page":"10","article-title":"Antineutrophil cytoplasmic antibodies in synovial fluid and in serum of patients with rheumatoid arthritis and other types of synovitis","volume":"23","author":"Afeltra","year":"1996","journal-title":"J Rheumatol"},{"key":"2025082700190164000_14.2.e238153.6","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0341-2"},{"key":"2025082700190164000_14.2.e238153.7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5414\/CNCS109036","article-title":"Antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis associated with mantle cell lymphoma","volume":"5","author":"Miyata","year":"2017","journal-title":"Clin Nephrol Case Stud"},{"key":"2025082700190164000_14.2.e238153.8","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-015-0583-y","article-title":"Mantle cell lymphoma first presenting as immune complex-mediated glomerulonephritis: a case report","volume":"9","author":"Abeysekera","year":"2015","journal-title":"J Med Case Rep"},{"key":"2025082700190164000_14.2.e238153.9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/nep.12925","article-title":"Mini review: a unique case of crescentic C3 glomerulonephritis","volume":"22","author":"Palamuthusingam","year":"2017","journal-title":"Nephrology"},{"key":"2025082700190164000_14.2.e238153.10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/RHU.0000000000000649","article-title":"The first case of lupus nephritis developing in a patient with mantle cell lymphoma","volume":"24","author":"Horino","year":"2018","journal-title":"J Clin Rheumatol"},{"key":"2025082700190164000_14.2.e238153.11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5414\/CN108462","article-title":"Parenchymal infiltration and lymphoma-associated membranoproliferative pattern of glomerular injury: an unusual presentation of mantle cell lymphoma","volume":"84","author":"Sekulic","year":"2015","journal-title":"Clin Nephrol"},{"key":"2025082700190164000_14.2.e238153.12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.5414\/CNP61422","article-title":"Proliferative glomerulonephritis associated with mantle cell lymphoma--natural history and effect of treatment in 2 cases","volume":"61","author":"Karim","year":"2004","journal-title":"Clin Nephrol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:19:10Z","timestamp":1756279150000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,5]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-238153"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238153","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}