{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:02:38Z","timestamp":1770357758904,"version":"3.49.0"},"reference-count":36,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,23]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Oncogenic osteomalacia (OO) is an uncommon paraneoplastic syndrome occurring due to the presence of a tumour that oversecretes fibroblast growth factor-23, which impairs renal phosphate handling. In most cases, the tumour is a morphologically distinct entity called \u2018phosphaturic mesenchymal tumour\u2019 (PMT). Spinal tumours causing OO are exceedingly rare. A 55-year-old man presented with multiple bone pain and proximal muscle weakness in the lower limbs. The constellation of biochemical findings (hypophosphataemia, normocalcaemia, increased alkaline phosphatase, low\u2013normal serum vitamin D and hyperphosphaturia) with radiographical rarefaction of the skeleton and pseudofractures led us to consider OO as a possibility. Functional imaging (<jats:sup>68<\/jats:sup>Ga DOTA-NOC positron emission tomography\/CT scan) localised the tumour to the D2 vertebra. Complete surgical resection led to resolution of symptoms, improved ambulatory status, normalisation of biochemical parameters and healing of pseudofractures. PMT should be considered in the differential diagnosis of hypophosphataemic osteomalacia with hyperphosphaturia. Tumour localisation with functional imaging and complete surgical resection produces satisfactory outcome.<\/jats:p>","DOI":"10.1136\/bcr-2020-238209","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T17:42:42Z","timestamp":1608140562000},"page":"e238209","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Oncogenic osteomalacia due to phosphaturic mesenchymal tumour in the upper thoracic spine"],"prefix":"10.1136","volume":"13","author":[{"given":"Bhavuk","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2790-3843","authenticated-orcid":false,"given":"Nishank","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-7625","authenticated-orcid":false,"given":"Archit","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Khadgawat","sequence":"additional","affiliation":[{"name":"Endocrinology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"2025082722530756000_13.12.e238209.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe030037"},{"key":"2025082722530756000_13.12.e238209.2","doi-asserted-by":"crossref","DOI":"10.1186\/s12957-015-0589-3","article-title":"En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review","volume":"13","author":"Meng","year":"2015","journal-title":"World J Surg Oncol"},{"key":"2025082722530756000_13.12.e238209.3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00001"},{"key":"2025082722530756000_13.12.e238209.4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41379-018-0100-0","article-title":"Phosphaturic mesenchymal tumor with an admixture of epithelial and mesenchymal elements in the jaws: clinicopathological and immunohistochemical analysis of 22 cases with literature review","volume":"32","author":"Wu","year":"2019","journal-title":"Mod Pathol"},{"key":"2025082722530756000_13.12.e238209.5","first-page":"33","article-title":"Osteomalacia with Looser's nodes (Milkman's syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years","volume":"16","author":"McCANCE","year":"1947","journal-title":"Q J Med"},{"key":"2025082722530756000_13.12.e238209.6","first-page":"554","article-title":"[Rickets following bone tumor]","volume":"14","author":"Prader","year":"1959","journal-title":"Helv Paediatr Acta"},{"key":"2025082722530756000_13.12.e238209.7","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200207000-00003"},{"key":"2025082722530756000_13.12.e238209.8","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301264"},{"key":"2025082722530756000_13.12.e238209.9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-Q"},{"key":"2025082722530756000_13.12.e238209.10","unstructured":"Fletcher C , Bridge J , Hogendoorn P , et al . 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