{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:59:11Z","timestamp":1762001951178,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Prolonged exposure to benzodiazepines (BDZ) may contribute towards physical dependence, which is manifested by iatrogenic Benzodiazepine Withdrawal Syndrome (BWS), a condition often underdiagnosed. Current evidence recommends precluding BDZ infusion as sedation in the intensive care unit to avoid possible withdrawal and delirium issues. Administration of dexmedetomidine should be considered to facilitate weaning in patients with BWS.<\/jats:p>","DOI":"10.1136\/bcr-2020-238318","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T14:03:59Z","timestamp":1610114639000},"page":"e238318","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of benzodiazepine withdrawal syndrome in a severe traumatic brain injury patient"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3076-2116","authenticated-orcid":false,"given":"Ming Kai","family":"Teah","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Unit, Hospital Queen Elizabeth, Kota Kinabalu, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan Keng","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Unit, Hospital Queen Elizabeth, Kota Kinabalu, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin Teck Fui","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Unit, Hospital Queen Elizabeth, Kota Kinabalu, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tat Boon","family":"Yeap","sequence":"additional","affiliation":[{"name":"Medicine Based Disciplines Department, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"2025082709120758000_14.1.e238318.1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003299"},{"key":"2025082709120758000_14.1.e238318.2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.medin.2018.12.003","article-title":"Management of analgesia, sedation and delirium in Spanish intensive care units: a national two-part survey","volume":"43","author":"Garc\u00eda-S\u00e1nchez","year":"2019","journal-title":"Med Intensiva"},{"key":"2025082709120758000_14.1.e238318.3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.5152\/TJAR.2019.49799","article-title":"Sedation practices and preferences of Turkish intensive care physicians: a national survey","volume":"47","author":"\u00dcrkmez","year":"2019","journal-title":"Turk J Anaesthesiol Reanim"},{"key":"2025082709120758000_14.1.e238318.4","article-title":"Opioid and benzodiazepine withdrawal syndromes in trauma ICU patients: a prospective exploratory study","volume":"2","author":"Arroyo-Novoa","year":"2020","journal-title":"Crit Care Explor"},{"key":"2025082709120758000_14.1.e238318.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1983.tb02272.x"},{"key":"2025082709120758000_14.1.e238318.6","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a5689f"},{"key":"2025082709120758000_14.1.e238318.7","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1097\/CCM.0000000000001953","article-title":"Patient, process, and system predictors of iatrogenic withdrawal syndrome in critically ill Children*","volume":"45","author":"Best","year":"2017","journal-title":"Crit Care Med"},{"key":"2025082709120758000_14.1.e238318.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb18280.x"},{"key":"2025082709120758000_14.1.e238318.9","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199901000-00052"},{"key":"2025082709120758000_14.1.e238318.10","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000050773.70232.08"},{"key":"2025082709120758000_14.1.e238318.11","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200302000-00041"},{"key":"2025082709120758000_14.1.e238318.12","article-title":"Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients","volume":"1","author":"Chen","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2025082709120758000_14.1.e238318.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.304"},{"key":"2025082709120758000_14.1.e238318.14","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1378\/chest.15-1389","article-title":"Associations between different sedatives and ventilator-associated events, length of stay, and mortality in patients who were mechanically ventilated","volume":"149","author":"Klompas","year":"2016","journal-title":"Chest"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:12:16Z","timestamp":1756311136000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,8]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-238318"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238318","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}