{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:52:40Z","timestamp":1781027560717,"version":"3.54.1"},"reference-count":25,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,20]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Melkersson-Rosenthal syndrome (MRS) is a rare neurocutaneous syndrome characterised by the triad of recurrent orofacial swelling, facial nerve palsy and fissured tongue. This diagnosis is particularly rare in children. We aim to increase awareness of the syndromic association of these clinical features since most patients present with a monosymptomatic form, reiterating the importance of detailed history and thorough physical examination, for the timely identification of these patients. Not only the recurring of symptoms, but also the association of MRS with other medical conditions, make \u2018earlier\u2019 diagnosis of the Syndrome beneficial. The average delay in diagnosis is 4\u20139 years. Although most cases resolve without treatment, when treated,steroids are most commonly used. Variable options have been tried for refractory and frequently recurrent cases. We present a case of MRS in a 12-year-old girl, diagnosed 3 years after onset of symptoms. We reviewed updated literature for MRS and associated clinical conditions as well as published treatment options.<\/jats:p>","DOI":"10.1136\/bcr-2020-238431","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T10:35:49Z","timestamp":1623407749000},"page":"e238431","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Rare diagnosis of Melkersson-Rosenthal syndrome in a paediatric patient"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-3581","authenticated-orcid":false,"given":"Anuradha","family":"Pavuluri","sequence":"first","affiliation":[{"name":"Pediatrics, Medical Center Navicent Health, Macon, Georgia, USA"},{"name":"Pediatrics, Mercer University, Macon, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-7229","authenticated-orcid":false,"given":"Stephanie","family":"Smith","sequence":"additional","affiliation":[{"name":"Pediatrics, Medical Center Navicent Health, Macon, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-1073","authenticated-orcid":false,"given":"Umesh","family":"Narsinghani","sequence":"additional","affiliation":[{"name":"Pediatrics, Medical Center Navicent Health, Macon, Georgia, USA"},{"name":"Pediatrics, Mercer University, Macon, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"2025082723194848000_14.6.e238431.1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1573396314666180515113941","article-title":"A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome","volume":"14","author":"Wehl","year":"2018","journal-title":"Curr Pediatr Rev"},{"key":"2025082723194848000_14.6.e238431.2","first-page":"737","article-title":"Ett fall AV recidiverende facialispares I samband Med angio-neurotiski oedem","volume":"90","author":"Melkersson","year":"1928","journal-title":"Hygiea"},{"key":"2025082723194848000_14.6.e238431.3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02865984","article-title":"Gemeinsames Auftreten von (recidivierender famili'rer) Facialislahmung, angio-neurotischem Gesichtsoedem und lingua plicata in Arthritismus-familien","volume":"131","author":"Rosenthal","year":"1931","journal-title":"Zeitsch Neurol Psych"},{"key":"2025082723194848000_14.6.e238431.4","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16071289","article-title":"Melkersson\u2013Rosenthal syndrome in childhood: report of three paediatric cases and a review of the literature","volume":"16","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"2025082723194848000_14.6.e238431.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6603-6"},{"key":"2025082723194848000_14.6.e238431.6","first-page":"541","article-title":"Recurrent facial nerve paresis and facial swelling","volume":"110","author":"Ehmann","year":"1962","journal-title":"Mschr. 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