{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:05:33Z","timestamp":1790121933318,"version":"4.0.1"},"reference-count":10,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,21]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Fracture healing has four phases: haematoma formation, soft callus, hard callus and remodelling. Often, non-healing fractures have an arrest of one of these phases, which need resurgery. We have repurposed denosumab for impaired fracture healing cases to avoid surgical intervention. Here, we report a series of three cases of impaired fracture healing where denosumab was given 120\u2009mg subcutaneous dosages for 3 months to enhance healing. All the three cases have shown complete bone union at a mean follow-up of 6.7 months (5\u20139 months) as assessed clinically and radiologically, and have observed no adverse effect of the therapy. Denosumab given in this dose aids fracture healing by increasing callus volume, density and bridges the fracture gap in recalcitrant fracture healing cases where the callus fails to consolidate.<\/jats:p>","DOI":"10.1136\/bcr-2020-238460","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T10:55:45Z","timestamp":1612781745000},"page":"e238460","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Repurposing denosumab for recalcitrant bone healing"],"prefix":"10.1136","volume":"14","author":[{"given":"Sanjay","family":"Agarwala","sequence":"first","affiliation":[{"name":"Orthopedics, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Vijayvargiya","sequence":"additional","affiliation":[{"name":"Orthopedics, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"2025082707305587000_14.2.e238460.1","first-page":"11","article-title":"Can an anti-fracture agent heal fractures?","volume":"7","author":"Einhorn","year":"2010","journal-title":"Clin Cases Miner Bone Metab"},{"key":"2025082707305587000_14.2.e238460.2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081113"},{"key":"2025082707305587000_14.2.e238460.3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.7101"},{"key":"2025082707305587000_14.2.e238460.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70277-8"},{"key":"2025082707305587000_14.2.e238460.5","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0578"},{"key":"2025082707305587000_14.2.e238460.6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11914-018-0432-1","article-title":"Clinical and research approaches to treat non-union fracture","volume":"16","author":"Schlundt","year":"2018","journal-title":"Curr Osteoporos Rep"},{"key":"2025082707305587000_14.2.e238460.7","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00774"},{"key":"2025082707305587000_14.2.e238460.8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2165\/11203300-000000000-00000","article-title":"Denosumab: a review of its use in the treatment of postmenopausal osteoporosis","volume":"28","author":"Moen","year":"2011","journal-title":"Drugs Aging"},{"key":"2025082707305587000_14.2.e238460.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3331-7"},{"key":"2025082707305587000_14.2.e238460.10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4236\/ojo.2020.105012","article-title":"Repurposing denosumab to stabilize acetabular Protrusio: Obviating surgery","volume":"10","author":"Agarwala","year":"2020","journal-title":"Open J Orthop"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:31:03Z","timestamp":1756305063000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,8]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-238460"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238460","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}