{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:59:20Z","timestamp":1777067960935,"version":"3.51.4"},"reference-count":8,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","award":["BHR-R-12-20-572"],"award-info":[{"award-number":["BHR-R-12-20-572"]}],"id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,7]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>A male infant, born preterm at 32 weeks of gestation, was referred at 36-week postmenstrual age for retinopathy of prematurity (ROP) screening. He had nystagmus, generalised hypopigmentation of skin, hair and eyes with preaxial polydactyly. The fundus was depigmented with prominently visible choroidal vessels. The retinal vessels were dilated, tortuous at zone 1. There was presence of arcading, shunting of vessels with presence of vitreous haemorrhage in the left eye. A diagnosis of aggressive posterior retinopathy of prematurity (APROP) in association with oculocutaneous albinism (OCA) was made.<\/jats:p>\n               <jats:p>Half-dose intravitreal bevacizumab was used to treat the vascular condition. After 2 weeks, there was complete regression of APROP with a completely mature retina observed at 4 months post-treatment. Herein, we describe the role of red-free light for screening ROP in infants with OCA; challenges in the management of ROP with laser photocoagulation compared with intravitreal anti-vascular endothelial growth factor therapy.<\/jats:p>","DOI":"10.1136\/bcr-2020-238490","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T16:47:27Z","timestamp":1612198047000},"page":"e238490","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Management of aggressive posterior retinopathy of prematurity in oculocutaneous albinism"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8594-6126","authenticated-orcid":false,"given":"Bhavik","family":"Panchal","sequence":"first","affiliation":[{"name":"Department of Vitreoretina and Uveitis, LV Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Vitreoretina and Uveitis, LV Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"2025082804144388000_14.2.e238490.1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-43"},{"key":"2025082804144388000_14.2.e238490.2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1468-3083.2003.00767.x","article-title":"Oculocutaneous albinism","volume":"17","author":"Okulicz","year":"2003","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025082804144388000_14.2.e238490.3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"2025082804144388000_14.2.e238490.4","doi-asserted-by":"crossref","first-page":"960","DOI":"10.4103\/ijo.IJO_931_17","article-title":"Retinopathy of prematurity in oculocutaneous albinism","volume":"67","author":"Chandra","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"2025082804144388000_14.2.e238490.5","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000867","article-title":"Incidence and risk factors for retinopathy of prematurity in multiple gestations: a Chinese population study","volume":"94","author":"Yau","year":"2015","journal-title":"Medicine"},{"key":"2025082804144388000_14.2.e238490.6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/ijo.IJO_1827_19","article-title":"Operational guidelines for ROP in India: a summary","volume":"68","author":"Shukla","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"2025082804144388000_14.2.e238490.7","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4103\/0301-4738.118449","article-title":"Impact of the day-30 screening strategy on the disease presentation and outcome of retinopathy of prematurity. the Indian twin cities retinopathy of prematurity report number 3","volume":"62","author":"Jalali","year":"2014","journal-title":"Indian J Ophthalmol"},{"key":"2025082804144388000_14.2.e238490.8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4103\/ijo.IJO_768_18","article-title":"Successful treatment of aggressive posterior retinopathy of prematurity with diode laser in ocular albinism: a case report","volume":"67","author":"Gangwe","year":"2019","journal-title":"Indian J Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:14:48Z","timestamp":1756379688000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,1]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-238490"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238490","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}