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The patient was diagnosed with a choroidal metastasis and was referred urgently to the oncology team who confirmed the presence of non-small cell lung cancer with distant metastases. He started treatment with alectinib (second-generation tyrosine kinase inhibitor). A few weeks later, his vision improved and, on examination, there was complete resolution of the choroidal mass and the associated subretinal fluid. Alectinib led to rapid resolution of his choroidal secondary and has excellent ocular safety profile.<\/jats:p>","DOI":"10.1136\/bcr-2020-238573","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:56:02Z","timestamp":1621857362000},"page":"e238573","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Rapid resolution of choroidal metastatic tumour secondary to lung cancer following treatment with alectinib"],"prefix":"10.1136","volume":"14","author":[{"given":"Ahmed","family":"AL-Janabi","sequence":"first","affiliation":[{"name":"Ophthalmology Department, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Thu","family":"Han","sequence":"additional","affiliation":[{"name":"James Paget University Hospital NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Busby","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J L","family":"Burton","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"2025082711570986000_14.5.e238573.1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0007-0971(68)80028-2","article-title":"Metastasis of bronchial carcinoma to the eye","volume":"62","author":"Sakula","year":"1968","journal-title":"Br J Dis Chest"},{"key":"2025082711570986000_14.5.e238573.2","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1001\/archopht.116.10.1396","article-title":"Solitary choroidal metastasis as the first sign of metastatic lung carcinoid","volume":"116","author":"Kreusel","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"2025082711570986000_14.5.e238573.3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s12032-008-9053-3","article-title":"Choroidal mass as an initial presentation of lung cancer","volume":"25","author":"Simsek","year":"2008","journal-title":"Med Oncol"},{"key":"2025082711570986000_14.5.e238573.4","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31819c9a73"},{"key":"2025082711570986000_14.5.e238573.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30148-1"},{"key":"2025082711570986000_14.5.e238573.6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/CAD.0000000000000848","article-title":"A rare case of non-small cell lung cancer choroidal metastasis responding to ALK tyrosine kinase inhibitors","volume":"31","author":"Scotti","year":"2020","journal-title":"Anticancer Drugs"},{"key":"2025082711570986000_14.5.e238573.7","first-page":"61","article-title":"Bilateral choroidal metastases as an initial manifestation of small-cell carcinoma of the lung","volume":"54","author":"Ko\u00e7ak","year":"2006","journal-title":"Tuberk Toraks"},{"key":"2025082711570986000_14.5.e238573.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.014"},{"key":"2025082711570986000_14.5.e238573.9","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-8-1"},{"key":"2025082711570986000_14.5.e238573.10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.2.159"},{"key":"2025082711570986000_14.5.e238573.11","article-title":"Development of a new choroidal metastasis in resistance to crizotinib therapy in anaplastic lymphoma kinase-rearranged non-small cell lung cancer","volume":"10","author":"Cui","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"2025082711570986000_14.5.e238573.12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ctrv.2014.09.006","article-title":"Management of choroidal metastases","volume":"40","author":"Jardel","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"2025082711570986000_14.5.e238573.13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.sjopt.2013.06.011","article-title":"Ocular metastasis of lung adenocarcinoma with ELM4-ALK translocation: a case report with a review of the literature","volume":"27","author":"Jiang","year":"2013","journal-title":"Saudi J Ophthalmol"},{"key":"2025082711570986000_14.5.e238573.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.04.002"},{"key":"2025082711570986000_14.5.e238573.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214886"},{"key":"2025082711570986000_14.5.e238573.16","unstructured":"National Institute for Health and Care Excellence . 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