{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:23Z","timestamp":1756339463171,"version":"3.44.0"},"reference-count":34,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,20]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>We herein report a woman who was suffering from type 1 diabetes and hearing impairment and whose mother had mitochondrial disease. Abdominal ultrasound identified a hepatic tumour, and a further examination led to the diagnosis of rectal cancer with synchronous multiple liver metastases. A genetic test led to the diagnosis of mitochondrial disease with a mitochondrial gene 3243A&gt;G mutation. After neoadjuvant chemotherapy, we performed hepatectomy and low anterior resection in one stage. Hepatic vascular exclusion was not performed in order to prevent damage to hepatocytes due to liver ischaemia, and Ringer\u2019s lactate solution was not used to prevent lactic acidosis. The postoperative course was uneventful. Only one other case involving hepatectomy being performed in a patient with mitochondrial disease has been reported. Considering the extreme rarity of such cases and the importance of perioperative management, we report this case here.<\/jats:p>","DOI":"10.1136\/bcr-2020-238653","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T07:26:24Z","timestamp":1612682784000},"page":"e238653","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatectomy for liver metastasis from rectal cancer in a patient with mitochondrial disease"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-8383","authenticated-orcid":false,"given":"Shogo","family":"Takei","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusei","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"2025082707200400000_14.2.e238653.1","first-page":"213","article-title":"Concept and classificaiton of mitochondrial diseases (broad definition). mitochondria and mitochondrial diseases","volume":"60","author":"Goto","year":"2002","journal-title":"Nihon Rinsho"},{"key":"2025082707200400000_14.2.e238653.2","unstructured":"The Japanese Society of Mitochondrial Research and Medicine . Mitochondrial disease diagnostic manual editing Committee, mitochondrial disease diagnostic manual: Shindan to Chiryo SHA, 2016."},{"key":"2025082707200400000_14.2.e238653.3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21710"},{"key":"2025082707200400000_14.2.e238653.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-009-4145-z"},{"key":"2025082707200400000_14.2.e238653.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1998.00725.x"},{"key":"2025082707200400000_14.2.e238653.6","first-page":"649","article-title":"[Anesthetic management of a patient with mitochondrial encephalomyopathy]","volume":"49","author":"Izuta","year":"2000","journal-title":"Masui"},{"key":"2025082707200400000_14.2.e238653.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68970-8"},{"key":"2025082707200400000_14.2.e238653.8","unstructured":"Bruce A , Dennis B , Karen H . Essential cell biology (2nd edition): Garland Science\/Taylor and Francis group, 2003."},{"key":"2025082707200400000_14.2.e238653.9","doi-asserted-by":"publisher","DOI":"10.1038\/13779"},{"key":"2025082707200400000_14.2.e238653.10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJM199509073331007","article-title":"Mitochondrial DNA and disease","volume":"333","author":"Johns","year":"1995","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025082707200400000_14.2.e238653.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.09.005"},{"key":"2025082707200400000_14.2.e238653.12","first-page":"1","article-title":"Midochondrial diseases","volume":"75","author":"Goto","year":"2016","journal-title":"Memai Heiko Igaku"},{"key":"2025082707200400000_14.2.e238653.13","first-page":"49","article-title":"Mitodhoncrial diseases","volume":"63","author":"Imai","year":"2014","journal-title":"Masui"},{"key":"2025082707200400000_14.2.e238653.14","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.6.746"},{"key":"2025082707200400000_14.2.e238653.15","doi-asserted-by":"publisher","DOI":"10.1038\/ng0892-368"},{"key":"2025082707200400000_14.2.e238653.16","first-page":"691","article-title":"A case of maternally inherited diabetes and deafness (MIDD) with hypertrophic cardiomyopathy","volume":"30","author":"Yamamoto","year":"1998","journal-title":"Shinzo"},{"key":"2025082707200400000_14.2.e238653.17","first-page":"2606","article-title":"Clinical image of diabetes in a family with mitochondrial encephalomyopathy, MELAS, MERRF, and CPEO","volume":"52","author":"Suzuki","year":"1994","journal-title":"Nihon Rinsho"},{"key":"2025082707200400000_14.2.e238653.18","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K07E-091"},{"key":"2025082707200400000_14.2.e238653.19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2957\/kanzo.56.313","article-title":"Liver and oxidative stress","volume":"56","author":"Tsubouchi","year":"2015","journal-title":"Kanzo"},{"key":"2025082707200400000_14.2.e238653.20","unstructured":"Ibi T , Nakao S , Sahashi K . Mitocondrial diseases (narrow definition) Symptomatological discussions, liver failure. Nihon Rinsho 2002:559\u201362."},{"key":"2025082707200400000_14.2.e238653.21","first-page":"431","article-title":"[A case of intraoperative cardiac arrest in a patient with mitochondrial encephalomyopathy undergoing lung resection]","volume":"62","author":"Kawagoe","year":"2013","journal-title":"Masui"},{"key":"2025082707200400000_14.2.e238653.22","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199708000-00030"},{"key":"2025082707200400000_14.2.e238653.23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1213\/01.ANE.0000081787.94275.DE","article-title":"Anesthesia for corrective spinal surgery in a patient with Leigh's disease","volume":"97","author":"Cooper","year":"2003","journal-title":"Anesth Analg"},{"key":"2025082707200400000_14.2.e238653.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.11.004"},{"key":"2025082707200400000_14.2.e238653.25","first-page":"801","article-title":"Pharmacokinetic study on the hepatic uptake of indocyanine green in cirrhotic patients","volume":"80","author":"Kawasaki","year":"1985","journal-title":"Am J Gastroenterol"},{"key":"2025082707200400000_14.2.e238653.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80227-X"},{"key":"2025082707200400000_14.2.e238653.27","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7084"},{"key":"2025082707200400000_14.2.e238653.28","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199601000-00011"},{"key":"2025082707200400000_14.2.e238653.29","first-page":"447","article-title":"Micromorphological changes in the regenerating liver of rat following resection and quantitative analysis by morphological measurement","volume":"88","author":"Nagahori","year":"1987","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"2025082707200400000_14.2.e238653.30","first-page":"173","article-title":"Surgical research started from mitochondria","volume":"31","author":"Yamamoto","year":"2004","journal-title":"Akita igaku"},{"key":"2025082707200400000_14.2.e238653.31","first-page":"382","article-title":"Circulatory dynamics and arterial ketone body ratio during blocked hepatic blood flow","volume":"42","author":"Nakagawa","year":"1993","journal-title":"Masui"},{"key":"2025082707200400000_14.2.e238653.32","first-page":"13","article-title":"Anterior approach to dorsal short hepatic and right hepatic veins in a right hepatic lobectomy","volume":"65","author":"Shimahara","year":"1996","journal-title":"Nihon Geka Hokan"},{"key":"2025082707200400000_14.2.e238653.33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/eci.12639","article-title":"Mitochondrial bioenergetics and posthepatectomy liver dysfunction","volume":"46","author":"Alexandrino","year":"2016","journal-title":"Eur J Clin Invest"},{"key":"2025082707200400000_14.2.e238653.34","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-006-0449-y"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:20:16Z","timestamp":1756304416000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,5]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-238653"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238653","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}