{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:32:20Z","timestamp":1791261140264,"version":"4.1.0"},"reference-count":31,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,23]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>This case represents a rare fulminant course of fried-rice associated food poisoning in an immunocompetent person due to pre-formed exotoxin produced by <jats:italic>Bacillus cereus<\/jats:italic>, with severe manifestations of sepsis, including multi-organ (hepatic, renal, cardiac, respiratory and neurological) failure, shock, metabolic acidosis, rhabdomyolysis and coagulopathy. Despite maximal supportive measures (continuous renal replacement therapy, plasmapheresis, N-acetylcysteine infusion and blood products, and broad-spectrum antimicrobials) and input from a multidisciplinary team (consisting of infectious diseases, intensive care, gastroenterology, surgery, toxicology, immunology and haematology), mortality resulted. This case is the first to use whole genome sequencing techniques to confirm the toxigenic potential of <jats:italic>B. cereus<\/jats:italic>. It has important implications for food preparation and storage, particularly given its occurrence in home isolation during the COVID-19 pandemic.<\/jats:p>","DOI":"10.1136\/bcr-2020-238716","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T12:10:28Z","timestamp":1610971828000},"page":"e238716","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Fulminant <i>Bacillus cereus<\/i> food poisoning with fatal multi-organ failure"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2418-7274","authenticated-orcid":false,"given":"Clinton M G","family":"Colaco","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Westmead, Sydney, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Basile","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Westmead, Sydney, Australia"},{"name":"Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Draper","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Westmead, Sydney, Australia"},{"name":"Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Westmead, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2025082700275909000_14.1.e238716.1","unstructured":"Pickering L , Baker C , Kimberlin D . Red book: 2009 report of the Committee on infectious diseases. 28th ed. Elk Grove Village: American Academy of Pediatrics, 2009: 227\u20138."},{"key":"2025082700275909000_14.1.e238716.2","unstructured":"Mandell G , Dolin R , Bennett J . Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Churchill Livingstone, 2009: 2727\u201331."},{"key":"2025082700275909000_14.1.e238716.3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1056\/NEJM197801192980306","article-title":"Bacillus cereus food poisoning","volume":"298","author":"Terranova","year":"1978","journal-title":"N Engl J Med"},{"key":"2025082700275909000_14.1.e238716.4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1745-4581.1993.tb00282.x","article-title":"Bacillus cereus pathogenicity: a review","volume":"2","author":"FERMANIAN","year":"1993","journal-title":"J Rapid Methods Autom Microbiol"},{"key":"2025082700275909000_14.1.e238716.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2319"},{"key":"2025082700275909000_14.1.e238716.6","unstructured":"Bennett JE , Dolin R , Blaser MJ . Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases. 9th ed. Elsevier, 2019."},{"key":"2025082700275909000_14.1.e238716.7","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318170f2ae"},{"key":"2025082700275909000_14.1.e238716.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704173361604"},{"key":"2025082700275909000_14.1.e238716.9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.4277-4279.2005"},{"key":"2025082700275909000_14.1.e238716.10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05129-11"},{"key":"2025082700275909000_14.1.e238716.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2009.09.004"},{"key":"2025082700275909000_14.1.e238716.12","unstructured":"Seemann T , da S AG , DM B , et al . Nullarbor [Internet]. Github. Available: https:\/\/github.com\/tseemann\/nullarbor"},{"key":"2025082700275909000_14.1.e238716.13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"2025082700275909000_14.1.e238716.14","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0090-6"},{"key":"2025082700275909000_14.1.e238716.15","unstructured":"NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology. Virulence Factors of Pathogenic Bacteria [Internet]. Available: http:\/\/www.mgc.ac.cn\/cgi-bin\/VFs\/genus.cgi?Genus=Bacillus"},{"key":"2025082700275909000_14.1.e238716.16","unstructured":"Geneious. Geneious - Bioinformatics software for Sequence Data Analysis."},{"key":"2025082700275909000_14.1.e238716.17","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00144"},{"key":"2025082700275909000_14.1.e238716.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1997.tb12776.x"},{"key":"2025082700275909000_14.1.e238716.19","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9432(76)90024-8"},{"key":"2025082700275909000_14.1.e238716.20","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12378"},{"key":"2025082700275909000_14.1.e238716.21","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.038547-0"},{"key":"2025082700275909000_14.1.e238716.22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01160201","article-title":"Eine t\u00f6dlich verlaufene Lebensmittelvergiftung durch Bacillus cereus","volume":"80","author":"Dirnhofer","year":"1977","journal-title":"Z Rechtsmed"},{"key":"2025082700275909000_14.1.e238716.23","unstructured":"Tran H , Juergens A . Mushroom toxicity. Treasure Island (FL): StatPearls Publishing, 2020."},{"key":"2025082700275909000_14.1.e238716.24","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(95)00012-6"},{"key":"2025082700275909000_14.1.e238716.25","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)00269-0"},{"key":"2025082700275909000_14.1.e238716.26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765x.2000.00835.x"},{"key":"2025082700275909000_14.1.e238716.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb07071.x"},{"key":"2025082700275909000_14.1.e238716.28","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199909000-00018"},{"key":"2025082700275909000_14.1.e238716.29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s13054-018-2220-9","article-title":"Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers","volume":"22","author":"Knaup","year":"2018","journal-title":"Crit Care"},{"key":"2025082700275909000_14.1.e238716.30","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21075"},{"key":"2025082700275909000_14.1.e238716.31","doi-asserted-by":"publisher","DOI":"10.1007\/BF03259930"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:28:09Z","timestamp":1756279689000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-238716"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238716","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}